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日本小儿脊柱侧弯手术的院内死亡率和发病率:使用全国住院患者数据库进行分析

In-hospital mortality and morbidity of pediatric scoliosis surgery in Japan: Analysis using a national inpatient database.

作者信息

Taniguchi Yuki, Oichi Takeshi, Ohya Junichi, Chikuda Hirotaka, Oshima Yasushi, Matsubayashi Yoshitaka, Matsui Hiroki, Fushimi Kiyohide, Tanaka Sakae, Yasunaga Hideo

机构信息

Department of Orthopedic Surgery, The University of Tokyo Hospital Department of Orthopedic Surgery, Japanese Red Cross Medical Center Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.

出版信息

Medicine (Baltimore). 2018 Apr;97(14):e0277. doi: 10.1097/MD.0000000000010277.

Abstract

Several previous reports have elucidated the mortality and incidence of complications after pediatric scoliosis surgery using nationwide databases. However, all of these studies were conducted in North America. Hence, this study aimed to identify the incidence and risk factors for in-hospital mortality and morbidity in pediatric scoliosis surgery, utilizing the Diagnosis Procedure Combination database, a national inpatient database in Japan.We retrospectively extracted data for patients aged less than 19 years who were admitted between 01 June 2010 and 31 March 2013 and underwent scoliosis surgery with fusion. The primary outcomes were in-hospital death and postoperative complications, including surgical site infection, ischemic heart disease, acute renal failure, pneumonia, stroke, disseminated intravascular coagulation, pulmonary embolism, and urinary tract infection.We identified 1,703 eligible patients (346 males and 1,357 females) with a mean age of 14.1 years. There were no deaths among the patients. At least one postoperative complication was found in 49 patients (2.9%). The most common complication was surgical site infection (1.4%). The multivariable logistic regression analysis showed that male sex (odds ratio, 2.22; 95% confidence interval, 1.28-3.70), comorbid diabetes (7.00; 1.56-31.51), and use of allogeneic blood transfusion (3.43; 1.86-6.41) were associated with the occurrence of postoperative complications. The present nationwide study elucidated the incidence and risk factors for in-hospital mortality and morbidity following surgery for pediatric scoliosis in an area other than North America. Diabetes was identified for the first time as a risk factor for postoperative complications in pediatric scoliosis surgery.

摘要

此前已有多项报告利用全国性数据库阐明了小儿脊柱侧弯手术后的死亡率和并发症发生率。然而,所有这些研究均在北美进行。因此,本研究旨在利用日本全国住院患者数据库“诊断程序组合”数据库,确定小儿脊柱侧弯手术住院期间死亡率和发病率的发生率及危险因素。我们回顾性提取了2010年6月1日至2013年3月31日期间入院且年龄小于19岁并接受了融合性脊柱侧弯手术患者的数据。主要结局为住院死亡和术后并发症,包括手术部位感染、缺血性心脏病、急性肾衰竭、肺炎、中风、弥散性血管内凝血、肺栓塞和尿路感染。我们确定了1703例符合条件的患者(346例男性和1357例女性),平均年龄为14.1岁。患者中无死亡病例。49例患者(2.9%)发现至少有一种术后并发症。最常见的并发症是手术部位感染(1.4%)。多变量逻辑回归分析显示,男性(比值比,2.22;95%置信区间,1.28 - 3.70)、合并糖尿病(7.00;1.56 - 31.51)和使用异体输血(3.43;1.86 - 6.41)与术后并发症的发生相关。本项全国性研究阐明了北美以外地区小儿脊柱侧弯手术后住院期间死亡率和发病率的发生率及危险因素。糖尿病首次被确定为小儿脊柱侧弯手术术后并发症的危险因素。

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