Hughes D T
Department of Chest Medicine, London Hospital, UK.
Postgrad Med J. 1987;63 Suppl 1:47-51.
Nocturnal asthma is a common and potentially dangerous condition. The mechanisms in its production are multifactorial. One factor appears to be increased vagal tone at night so that an anticholinergic drug might prove effective. The evidence for a bronchodilator action of anticholinergic drugs is reviewed. A clinical trial of one such anticholinergic in nocturnal asthma is described. In 12 patients with morning dipping a dose of 160 micrograms of ipratropium bromide inhaled at night significantly reduced the extent of morning dipping. The implications are discussed.
夜间哮喘是一种常见且可能危险的病症。其发病机制是多因素的。其中一个因素似乎是夜间迷走神经张力增加，因此抗胆碱能药物可能被证明是有效的。本文综述了抗胆碱能药物支气管扩张作用的证据。描述了一种此类抗胆碱能药物用于夜间哮喘的临床试验。在12例有晨间峰谷现象的患者中，夜间吸入160微克异丙托溴铵剂量可显著降低晨间峰谷现象的程度。并对其意义进行了讨论。
