异丙托溴铵用于夜间哮喘患者。
Ipratropium bromide in patients with nocturnal asthma.
作者信息
Cox I D, Hughes D T, McDonnell K A
出版信息
Postgrad Med J. 1984 Aug;60(706):526-8. doi: 10.1136/pgmj.60.706.526.
Abstract
Fourteen patients with nocturnal asthma were recruited to a two period crossover trial which compared a run-in period on nightly salbutamol (200 micrograms) with a period on nightly ipratropium bromide (160 micrograms) and a period on nightly salbutamol plus ipratropium at night. Morning dipping, as assessed by the fall in peak flow overnight, was significantly reduced in the periods when ipratropium bromide was taken. Peak flow in the morning and also at night was improved when taking ipratropium bromide. Ipratropium bromide in adequate dosage appears to be effective in reducing morning dipping in asthma.
摘要
招募了14名夜间哮喘患者参与一项两阶段交叉试验，该试验比较了每晚使用沙丁胺醇（200微克）的导入期、每晚使用异丙托溴铵（160微克）的阶段以及每晚同时使用沙丁胺醇和异丙托溴铵的阶段。通过夜间峰值流速下降来评估的晨峰现象，在服用异丙托溴铵的阶段显著降低。服用异丙托溴铵时，早晨和夜间的峰值流速均有所改善。适当剂量的异丙托溴铵似乎对减轻哮喘的晨峰现象有效。
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