State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Molecules. 2019 Apr 18;24(8):1541. doi: 10.3390/molecules24081541.
Natural products have played indispensable roles in drug development and biomedical research. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a group of fast-expanding natural products attribute to genome mining efforts in recent years. Most RiPP natural products were discovered from bacteria, yet many eukaryotic cyclic peptides turned out to be of RiPP origin. This review article presents recent advances in the discovery of eukaryotic RiPP natural products, the elucidation of their biosynthetic pathways, and the molecular basis for their biosynthetic enzyme catalysis.
天然产物在药物开发和生物医学研究中发挥了不可或缺的作用。核糖体合成和翻译后修饰肽（RiPPs）是近年来通过基因组挖掘发现的一组快速增长的天然产物。大多数 RiPP 天然产物是从细菌中发现的，但许多真核环肽也被证明是 RiPP 的起源。本文综述了真核 RiPP 天然产物的发现、生物合成途径的阐明以及生物合成酶催化的分子基础的最新进展。
