母体多不饱和脂肪酸的饮食摄入可改变产前滴滴涕暴露与儿童神经发育之间的关联：一项队列研究。
Maternal dietary intake of polyunsaturated fatty acids modifies association between prenatal DDT exposure and child neurodevelopment: A cohort study.
机构信息
Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Av. Universidad 655, Col. Santa María Ahuacatitlán, Cuernavaca, Morelos, Mexico.
Subdirección de Investigación en Intervenciones Comunitarias, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Calle Montes Urales 800, Miguel Hidalgo, Lomas Virreyes, Ciudad de México, Mexico.
出版信息
Environ Pollut. 2018 Jul;238:698-705. doi: 10.1016/j.envpol.2018.03.100. Epub 2018 Apr 2.
BACKGROUND
Maternal 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) serum levels during pregnancy have been negatively linked to child neurodevelopment in contrast to intake of omega-3 and -6 (ω-3 and ω-6) fatty acids.
OBJECTIVES
To assess whether maternal dietary intake of ω-3 and ω-6 during pregnancy modifies the association between exposure to DDE and child neurodevelopment from age 42-60 months.
METHODS
Prospective cohort study with 142 mother-child pairs performed in Mexico. DDE serum levels were determined by electron capture gas chromatography. Dietary ω-3 and ω-6 intake was estimated by questionnaire. Child neurodevelopment was assessed by McCarthy Scales.
RESULTS
Docosahexaenoic (DHA) fatty acid intake significantly modified the association between DDE and motor component: increased maternal DDE was associated with lower motor development in children whose mothers had lower DHA intake (β = -1.25; 95% CI: -2.62, 0.12), in contrast to the non-significant increase among children whose mothers had higher DHA intake (β = 0.50; 95% CI: 0.55, 1.56). Likewise, arachidonic fatty acid (ARA) intake modified the association between DDE and memory component: increased maternal DDE was associated with a significantly larger reduction in the memory component in children whose mothers had lower ARA intake (β = -1.31; 95% CI: -2.29, -0.32) than children whose mothers had higher ARA intake (β = 0.17; 95% CI: -0.78, 1.11).
CONCLUSIONS
Dietary intake of DHA and ARA during pregnancy may protect against child neurodevelopment damage associated with prenatal maternal DDE levels.
背景
与摄入 ω-3 和 ω-6（ω-3 和 ω-6）脂肪酸相反，母体怀孕期间的 1,1-二氯-2,2-双（对氯苯基）乙烯（DDE）血清水平与儿童神经发育呈负相关。
目的
评估母体怀孕期间摄入 ω-3 和 ω-6 是否会改变 DDE 暴露与 42-60 个月儿童神经发育之间的关联。
方法
在墨西哥进行了一项前瞻性队列研究，共有 142 对母婴参与。通过电子捕获气相色谱法测定 DDE 血清水平。通过问卷估计 ω-3 和 ω-6 的饮食摄入量。通过 McCarthy 量表评估儿童的神经发育。
结果
二十二碳六烯酸（DHA）脂肪酸的摄入量显著改变了 DDE 与运动成分之间的关联：母体 DDE 水平升高与 DHA 摄入量较低的儿童运动发育迟缓相关（β= -1.25；95%CI：-2.62，0.12），而 DHA 摄入量较高的儿童则没有显著增加（β= 0.50；95%CI：0.55，1.56）。同样，花生四烯酸（ARA）的摄入量也改变了 DDE 与记忆成分之间的关联：母体 DDE 水平升高与 ARA 摄入量较低的儿童记忆成分显著降低相关（β= -1.31；95%CI：-2.29，-0.32），而 ARA 摄入量较高的儿童则没有显著降低（β= 0.17；95%CI：-0.78，1.11）。
结论
怀孕期间 DHA 和 ARA 的饮食摄入可能有助于预防与母体产前 DDE 水平相关的儿童神经发育损伤。
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