Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC 27709-2233, USA.
Epidemiology. 2012 Sep;23(5):689-98. doi: 10.1097/EDE.0b013e31825fb61d.
Dichlorodiphenyltrichloroethane (DDT) continues to be used for control of infectious diseases in several countries. In-utero exposure to DDT and dichlorodiphenyldichloroethylene (DDE) has been associated with developmental and cognitive impairment among children. We examined this association in an historical cohort in which the level of exposure was greater than in previous studies.
The association of in-utero DDT and DDE exposure with infant and child neurodevelopment was examined in 1100 subjects in the Collaborative Perinatal Project, a prospective birth cohort enrolling pregnant women from 12 study centers in the United States from 1959 to 1965. Maternal DDT and DDE concentrations were measured in archived serum specimens. Infant mental and motor development was assessed at age 8 months using the Bayley Scales of Infant Development, and child cognitive development was assessed at age 7 years, using the Wechsler Intelligence Scale for Children.
Although levels of DDT and DDE were relatively high in this population (median DDT concentration, 8.9 μg/L; DDE, 24.5 μg/L), neither were related to Mental or Psychomotor Development scores on the Bayley Scales nor to Full-Scale Intelligence Quotient at 7 years of age. Categorical analyses showed no evidence of dose- response for either maternal DDT or DDE, and estimates of the association between continuous measures of exposure and neurodevelopment were indistinguishable from 0.
Adverse associations were not observed between maternal serum DDT and DDE concentrations and offspring neurodevelopment at 8 months or 7 years in this cohort.
滴滴涕（DDT）在一些国家仍被用于控制传染病。在子宫内接触滴滴涕和滴滴伊（DDE）与儿童发育和认知障碍有关。我们在一个历史队列中研究了这种关联，其中接触水平高于以往的研究。
在协作围产期项目（Collaborative Perinatal Project）中，我们检查了 1100 名受试者的宫内 DDT 和 DDE 暴露与婴儿和儿童神经发育之间的关联，该项目是一个前瞻性的出生队列，从 1959 年到 1965 年在美国 12 个研究中心招募孕妇。在存档的血清样本中测量了母体 DDT 和 DDE 浓度。婴儿的精神和运动发育在 8 个月时使用贝利婴儿发育量表（Bayley Scales of Infant Development）进行评估，儿童的认知发育在 7 岁时使用韦氏儿童智力量表（Wechsler Intelligence Scale for Children）进行评估。
尽管该人群的 DDT 和 DDE 水平相对较高（中位数 DDT 浓度为 8.9μg/L；DDE 为 24.5μg/L），但它们与贝利量表的精神或运动发育评分均无关，也与 7 岁时的全量表智商无关。分类分析表明，母体 DDT 或 DDE 均无剂量反应证据，暴露的连续测量与神经发育之间的关联估计与 0 无区别。
在该队列中，未观察到母体血清 DDT 和 DDE 浓度与 8 个月或 7 岁时子女神经发育之间存在不良关联。
