西尼罗河病毒宿主免疫与病毒致病机制研究的最新进展
Recent advances in understanding West Nile virus host immunity and viral pathogenesis.
作者信息
Luo Huanle, Wang Tian
机构信息
Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, USA.
Department of Pathology, University of Texas Medical Branch, Galveston, USA.
出版信息
F1000Res. 2018 Mar 19;7:338. doi: 10.12688/f1000research.13362.1. eCollection 2018.
Abstract
West Nile virus (WNV), a mosquito-borne flavivirus, has been a significant public health concern in the United States for nearly two decades. The virus has been linked to acute viral encephalitis, neurological sequelae, and chronic kidney diseases. Neither antiviral drugs nor vaccines are currently available for humans. cell culture and experimental animal models have been used to study WNV infection in humans. In this review, we will focus on recent findings and provide new insights into WNV host immunity and viral pathogenesis.
摘要
西尼罗河病毒（WNV）是一种由蚊子传播的黄病毒，近二十年来一直是美国重大的公共卫生问题。该病毒与急性病毒性脑炎、神经后遗症和慢性肾脏疾病有关。目前尚无针对人类的抗病毒药物或疫苗。细胞培养和实验动物模型已被用于研究人类的西尼罗河病毒感染。在这篇综述中，我们将聚焦于近期的研究发现，并对西尼罗河病毒的宿主免疫和病毒发病机制提供新的见解。
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