西尼罗河病毒中枢神经系统感染
West Nile Virus Infection in the Central Nervous System.
作者信息
Winkelmann Evandro R, Luo Huanle, Wang Tian
机构信息
Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, 77555, USA.
Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, 77555, USA; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, 77555, USA.
出版信息
F1000Res. 2016 Jan 26;5. doi: 10.12688/f1000research.7404.1. eCollection 2016.
Abstract
West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide. Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae. Neither antiviral drugs nor vaccines are available for humans. Animal models have been used to investigate WNV pathogenesis and host immune response in humans. In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.
摘要
西尼罗河病毒（WNV）是一种嗜神经的单链黄病毒，一直是全球虫媒病毒性脑炎的主要病因。据报道，在美国，高达50%的WNV康复患者有长期神经后遗症。目前尚无针对人类的抗病毒药物和疫苗。动物模型已被用于研究WNV在人类中的发病机制和宿主免疫反应。在这篇综述中，我们将讨论WNV感染动物模型研究的最新发现，并对WNV发病机制和WNV诱导的中枢神经系统宿主免疫提供新的见解。
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