Beazley-Long Nicholas, Durrant Alexandra M, Swift Matthew N, Donaldson Lucy F
Arthritis Research UK Pain Centre & School of Life Sciences, Medical School, University of Nottingham, Nottingham, UK.
F1000Res. 2018 Mar 20;7:341. doi: 10.12688/f1000research.13548.1. eCollection 2018.
Central nervous system (CNS) pericytes regulate critical functions of the neurovascular unit in health and disease. CNS pericytes are an attractive pharmacological target for their position within the neurovasculature and for their role in neuroinflammation. Whether the function of CNS pericytes also affects pain states and nociceptive mechanisms is currently not understood. Could it be that pericytes hold the key to pain associated with CNS blood vessel dysfunction? This article reviews recent findings on the important physiological functions of CNS pericytes and highlights how these neurovascular functions could be linked to pain states.
中枢神经系统（CNS）周细胞在健康和疾病状态下调节神经血管单元的关键功能。由于其在神经血管系统中的位置以及在神经炎症中的作用，CNS周细胞是一个有吸引力的药理学靶点。目前尚不清楚CNS周细胞的功能是否也会影响疼痛状态和伤害感受机制。周细胞是否是与CNS血管功能障碍相关疼痛的关键所在？本文综述了关于CNS周细胞重要生理功能的最新研究结果，并强调了这些神经血管功能如何与疼痛状态相关联。
