在越南腹泻儿童中检测到的猪样G3P[6]和G4P[6] A组轮状病毒毒株
Porcine-like G3P[6] and G4P[6] rotavirus A strains detected from children with diarrhoea in Vietnam.
作者信息
Kaneko Miho, Do Loan Phuong, Doan Yen Hai, Nakagomi Toyoko, Gauchan Punita, Agbemabiese Chantal Ama, Dang Anh Duc, Nakagomi Osamu
机构信息
Department of Molecular Epidemiology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
出版信息
Arch Virol. 2018 Aug;163(8):2261-2263. doi: 10.1007/s00705-018-3836-4. Epub 2018 Apr 5.
Animal rotavirus A (RVA) strains can infect children and cause diarrhoea. We determined the full genome sequences of one G3P[6] strain (NT0001) and five G4P[6] strains (NT0042, NT0077, NT0205, NT0599, and NT0621) detected from children with diarrhoea in Vietnam in 2007-2008. Strain NT0001 had a genotype constellation of: G3-P[6]-I5-R1-C1-M1-A8-N1-T1-E1-H1, strain NT0042: G4-P[6]-I1-R1-C1-M1-A8-N1-T1-E1-H1, strain NT0077: G4-P[6]-I5-R1-C1-M1-A8-N1-T7-E1-H1, and strains NT0205, NT0599, and NT0621: G4-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1. Sequence divergence data and phylogenetic analysis showed that they were different porcine RVA strains that independently and directly crossed the host species barrier to infect children.
动物轮状病毒A（RVA）毒株可感染儿童并导致腹泻。我们测定了2007 - 2008年从越南腹泻儿童中检测到的1株G3P[6]毒株（NT0001）和5株G4P[6]毒株（NT0042、NT0077、NT0205、NT0599和NT0621）的全基因组序列。毒株NT0001的基因型组合为：G3 - P[6] - I5 - R1 - C1 - M1 - A8 - N1 - T1 - E1 - H1，毒株NT0042：G4 - P[6] - I1 - R1 - C1 - M1 - A8 - N1 - T1 - E1 - H1，毒株NT0077：G4 - P[6] - I5 - R1 - C1 - M1 - A8 - N1 - T7 - E1 - H1，以及毒株NT0205、NT0599和NT0621：G4 - P[6] - I1 - R1 - C1 - M1 - A1 - N1 - T1 - E1 - H1。序列差异数据和系统发育分析表明，它们是不同的猪RVA毒株，独立且直接跨越宿主物种屏障感染儿童。
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