Nam You Seon, Lee Gyeongsil, Yun Jae Moon, Cho Belong
Department of Family Medicine, Seoul National University College of Medicine, Seoul, Korea.
Department of Family Medicine, Seoul National University Hospital, Seoul, Korea.
World J Mens Health. 2018 May;36(2):110-122. doi: 10.5534/wjmh.182001. Epub 2018 Mar 22.
Muscle strength and physical function decrease in older men, as do testosterone levels. Nonetheless, the effects of testosterone replacement therapy on muscle strength and physical function remain inconclusive and equivocal. We conducted a rapid systematic review, the results of which showed that testosterone replacement does not affect muscle strength (measured by hand grip strength and leg muscle strength), although it may increase physical function (measured by the 6-minute walk test, Physical Activity Scale for the Elderly score, and other physical performance tests). However, most of the studies were conducted in the United States or Europe and did not include participants from Asian or other ethnic backgrounds; therefore, further studies are needed to evaluate the effects of testosterone replacement in a broader population.
老年男性的肌肉力量和身体机能会下降，睾酮水平也是如此。尽管如此，睾酮替代疗法对肌肉力量和身体机能的影响仍不明确且存在争议。我们进行了一项快速系统综述，结果显示睾酮替代疗法不会影响肌肉力量（通过握力和腿部肌肉力量来衡量），不过它可能会增强身体机能（通过6分钟步行试验、老年人身体活动量表评分及其他身体性能测试来衡量）。然而，大多数研究是在美国或欧洲进行的，并未纳入来自亚洲或其他种族背景的参与者；因此，需要进一步开展研究以评估在更广泛人群中进行睾酮替代疗法的效果。
