雄激素剥夺治疗对前列腺癌患者肌少症发展的影响：系统评价。
Influence of Androgen Deprivation Therapy on the Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review.
机构信息
Department of Obesity Treatment, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, 60-569 Poznan, Poland.
Department of Ophthalmology and Optometry, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
出版信息
Nutrients. 2024 Feb 26;16(5):656. doi: 10.3390/nu16050656.
The changes in body composition during androgen deprivation therapy (ADT) in patients suffering from prostate cancer (PCa) are recognized by professionals more often as biomarker for effective treatment. The aim of this study was to investigate the impact of ADT on the sarcopenia development in PCa. The following databases were used: PubMed, Embase, Web of Science and Scopus databases. Out of 2183 studies, 7 were included in this review. The fixed-effect model was used in the meta-analysis. A significant increase in SATI (Subcutaneous Adipose Tissue Index) of 0.32 (95% CI: 0.13-0.51) = 0.001, decrease in SMI (Skeletal Muscle Index) of -0.38 (95% CI: -0.57 to -0.19) < 0.0001, and SMD (Skeletal Muscle Density) of -0.46 (95% CI: -0.69 to -0.24) < 0.0001 were observed. No statistical association was visible between ADT and changes in BMI (Body Mass Index), 0.05 (95% CI: -0.18-0.28), = 0.686, and VATI (Visceral Adipose Tissue Index): 0.17 (95% CI: -0.02 to 0.37), = 0.074. In conclusion, the ADT significantly contributes to the body composition changes and sarcopenia development.
去势治疗（ADT）期间前列腺癌（PCa）患者的身体成分变化更多地被专业人士视为有效治疗的生物标志物。本研究旨在探讨 ADT 对 PCa 患者发生肌肉减少症的影响。使用了以下数据库：PubMed、Embase、Web of Science 和 Scopus 数据库。在 2183 项研究中，有 7 项研究纳入了本综述。荟萃分析采用固定效应模型。Meta 分析显示 SATI（皮下脂肪组织指数）显著增加 0.32（95%CI：0.13-0.51）=0.001，SMI（骨骼肌指数）显著降低-0.38（95%CI：-0.57 至-0.19）<0.0001，SMD（骨骼肌密度）显著降低-0.46（95%CI：-0.69 至-0.24）<0.0001。ADT 与 BMI（体重指数）的变化之间无统计学关联，0.05（95%CI：-0.18-0.28）=0.686，与 VATI（内脏脂肪组织指数）的变化之间也无统计学关联：0.17（95%CI：-0.02 至 0.37）=0.074。总之，ADT 显著导致身体成分变化和肌肉减少症的发生。
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