Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu Sichuan Province, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu Sichuan Province, China.
Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu Sichuan Province, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu Sichuan Province, China.
Reprod Biomed Online. 2020 Feb;40(2):229-237. doi: 10.1016/j.rbmo.2019.10.019. Epub 2019 Nov 16.
There is increasing evidence that human papillomavirus (HPV) infection affects reproductive health and fertility, although its impact on female fertility has not been thoroughly studied. MEDLINE, Embase, CENTRAL, Web of Science, CNKI, Wanfang, VIP and ClinicalTrials.gov databases were systematically searched for relevant articles. A meta-analysis was conducted of 11 studies including 15,450 female subjects that compared HPV prevalence between the infertile and general population, and evaluated the association between HPV positivity and female infertility. Seven case-control studies on 3581 participants reported indiscriminate genotype infections (high-risk/low-risk [HR/LR]-HPV), but the random effects model revealed no association between HPV infection and female infertility (odds ratio [OR] 2.13, 95% confidence interval [CI] 0.97-4.65, P = 0.06). Six studies with a total of 11,869 participants reported HR-HPV infections alone, and the pooled data showed a significant association between HR-HPV infection and female infertility (OR 2.33, 95% CI 1.42-3.83, P = 0.0008). It was concluded that HR-HPV infection is a potential risk factor of female infertility, but not an independent cause. Further prospective studies are needed to assess the exact role of HPV in female infertility.
越来越多的证据表明，人乳头瘤病毒（HPV）感染会影响生殖健康和生育能力，尽管其对女性生育能力的影响尚未得到充分研究。我们系统地检索了 MEDLINE、Embase、CENTRAL、Web of Science、CNKI、万方、VIP 和 ClinicalTrials.gov 数据库中的相关文章。对 11 项研究（共纳入 15450 名女性受试者）进行了荟萃分析，这些研究比较了不孕人群和一般人群中的 HPV 流行率，并评估了 HPV 阳性与女性不孕之间的相关性。7 项针对 3581 名参与者的病例对照研究报告了无差别基因型感染（高危/低危型 HPV[HR/LR-HPV]），但随机效应模型显示 HPV 感染与女性不孕之间无关联（比值比[OR] 2.13，95%置信区间[CI] 0.97-4.65，P=0.06）。6 项共纳入 11869 名参与者的研究报告了 HR-HPV 感染单独情况，汇总数据显示 HR-HPV 感染与女性不孕之间存在显著相关性（OR 2.33，95% CI 1.42-3.83，P=0.0008）。结论：HR-HPV 感染是女性不孕的潜在危险因素，但不是独立原因。需要进一步的前瞻性研究来评估 HPV 在女性不孕中的确切作用。
