Zhou Xiao-Bin, Liu Na, Wang Dong, Zou De-Xin, Wei Chang-Wei, Zhou Jun-Lin
Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing; Department of Traumatic Orthopedics, the Third Hospital of Shijiazhuang, Shijiazhuang, Hebei Province, China.
Department of Internal Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Neural Regen Res. 2018 Mar;13(3):492-496. doi: 10.4103/1673-5374.228733.
Ischemic preconditioning or postconditioning has been shown to have neuroprotective effect on cerebral ischemia, but it has not been studied in peripheral nerve injury. In this study, a rat model of sciatic nerve transection was established, and subjected to three cycles of ischemia for 10 minutes + reperfusion for 10 minutes, once a day. After ischemic postconditioning, serum insulin-like growth factor 1 expression increased; sciatic nerve Schwann cell myelination increased; sensory function and motor function were restored. These findings indicate that ischemic postconditioning can effectively protect injured sciatic nerve. The protective effect is possibly associated with upregulation of insulin-like growth factor 1.
缺血预处理或后处理已被证明对脑缺血具有神经保护作用，但尚未在周围神经损伤中进行研究。在本研究中，建立了大鼠坐骨神经横断模型，每天进行3个周期的缺血10分钟+再灌注10分钟。缺血后处理后，血清胰岛素样生长因子1表达增加；坐骨神经施万细胞髓鞘形成增加；感觉功能和运动功能得到恢复。这些发现表明，缺血后处理可有效保护受损的坐骨神经。其保护作用可能与胰岛素样生长因子1的上调有关。
