无金属、用户友好的烯烃区域选择性羟氟化反应。
Metal-Free and User-Friendly Regioselective Hydroxyfluorination of Olefins.
机构信息
Departamento de Química Orgánica , Universidad de Valencia , E-46100 Burjassot , Spain.
Laboratorio de Moléculas Orgánicas , Centro de Investigación Príncipe Felipe , E-46012 Valencia , Spain.
出版信息
Org Lett. 2018 Apr 20;20(8):2338-2341. doi: 10.1021/acs.orglett.8b00681. Epub 2018 Apr 6.
Abstract
A simple, user-friendly, metal-free protocol for the regioselective anti-Markovnikov hydrofluorination of olefins using readily available and inexpensive reagents has been developed. This new approach displays a broader scope than previously reported methodologies and has been applied to the late-stage fluorination of a complex molecule, giving rise to a fluorosteroid derivative. The stereochemistry of the process has also been studied in some detail.
摘要
现已开发出一种简单、易用且无金属的烯烃反马氏规则区域选择性氢氟化协议，该协议使用易得且廉价的试剂。与先前报道的方法相比，这种新方法具有更广泛的应用范围，并已应用于复杂分子的后期氟代反应，得到了氟甾体衍生物。该过程的立体化学也进行了一些详细的研究。
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