Department of Radiology, National Hospital Organization Yamaguchi-Ube Medical Center, Ube, Japan.
Department of Pathology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Thorac Cancer. 2018 Jun;9(6):718-725. doi: 10.1111/1759-7714.12638. Epub 2018 Apr 6.
Pleomorphic carcinoma (PC) of the lung is a rare histological type of lung carcinoma. The association between computed tomography (CT) findings and histology with outcome remains unclear. We examined the relationships between CT features and histopathologic findings, and evaluated the impact of CT features and other clinicopathologic factors on survival.
Thirty-five consecutive patients with PC of the lung who underwent surgery between October 2010 and December 2015 were enrolled in this study. The 35 tumors were classified with or without air bronchogram in the tumors, and with or without intratumoral ground glass opacity (GGO) on CT.
Air bronchogram and GGO were detected in 12 (34.3%) and 5 (14.3%) tumors, respectively. Multivariate analysis revealed that air bronchogram was significantly associated with the presence of adenocarcinoma components with lepidic growth patterns (P = 0.005), and predominance of adenocarcinomas (P = 0.026). GGO was significantly associated with the presence of adenocarcinoma component with lepidic growth pattern (P = 0.010). Air bronchogram was an independent favorable prognostic factor for overall survival, whereas GGO did not have a significant effect on survival.
Air bronchogram observed in PCs of the lung is strongly related with histological components of the tumor and favorable outcome.
肺多形性癌（PC）是一种罕见的肺腺癌组织学类型。CT 表现与组织学表现与预后之间的关系尚不清楚。我们研究了 CT 特征与组织病理学发现之间的关系，并评估了 CT 特征和其他临床病理因素对生存的影响。
本研究纳入了 2010 年 10 月至 2015 年 12 月期间连续接受手术治疗的 35 例肺 PC 患者。35 个肿瘤在 CT 上分为有或无空气支气管征和有或无肿瘤内磨玻璃密度影（GGO）。
12 例（34.3%）肿瘤检测到空气支气管征，5 例（14.3%）肿瘤检测到 GGO。多变量分析显示，空气支气管征与具有贴壁生长模式的腺癌成分的存在显著相关（P=0.005），且与腺癌为主显著相关（P=0.026）。GGO 与具有贴壁生长模式的腺癌成分显著相关（P=0.010）。空气支气管征是总生存的独立预后良好因素，而 GGO 对生存无显著影响。
肺多形性癌中观察到的空气支气管征与肿瘤的组织学成分密切相关，并与良好的预后相关。
