Division of Research, Kaiser Permanente Northern California, Oakland.
Division of Research, Kaiser Permanente Northern California, Oakland.
Am J Med. 2018 Jul;131(7):829-836.e1. doi: 10.1016/j.amjmed.2018.02.014. Epub 2018 Apr 2.
Heart disease and stroke remain among the leading causes of death nationally. We examined whether differences in recent trends in heart disease, stroke, and total mortality exist in the United States and Kaiser Permanente Northern California (KPNC), a large integrated healthcare delivery system.
The main outcome measures were comparisons of US and KPNC total, age-specific, and sex-specific changes from 2000 to 2015 in mortality rates from heart disease, coronary heart disease, stroke, and all causes. The Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research data system was used to determine US mortality rates. Mortality rates for KPNC were determined from health system, Social Security vital status, and state death certificate databases.
Declines in age-adjusted mortality rates were noted in KPNC and the United States for heart disease (36.3% in KPNC vs 34.6% in the United States), coronary heart disease (51.0% vs 47.9%), stroke (45.5% vs 38.2%), and all-cause mortality (16.8% vs 15.6%). However, steeper declines were noted in KPNC than the United States among those aged 45 to 65 years for heart disease (48.3% KPNC vs 23.6% United States), coronary heart disease (55.6% vs 35.9%), stroke (55.8% vs 26.0%), and all-cause mortality (31.5% vs 9.1%). Sex-specific changes were generally similar.
Despite significant declines in heart disease and stroke mortality, there remains an improvement gap nationally among those aged less than 65 years when compared with a large integrated healthcare delivery system. Interventions to improve cardiovascular mortality in the vulnerable middle-aged population may play a key role in closing this gap.
心脏病和中风仍然是全美主要的死亡原因。我们研究了美国和凯撒永久医疗集团北加州(Kaiser Permanente Northern California,KPNC)这一大型综合医疗服务系统在心脏病、中风和总死亡率的近期趋势方面是否存在差异。
主要观察指标是比较 2000 年至 2015 年美国和 KPNC 全因、年龄别和性别别心脏病、冠心病、中风和全因死亡率的变化情况。使用疾病控制和预防中心广域在线流行病学研究数据系统确定美国的死亡率。通过医疗系统、社会保障生存状况和州死亡证明数据库确定 KPNC 的死亡率。
KPNC 和美国的心脏病(KPNC 下降 36.3%,美国下降 34.6%)、冠心病(KPNC 下降 51.0%,美国下降 47.9%)、中风(KPNC 下降 45.5%,美国下降 38.2%)和全因死亡率(KPNC 下降 16.8%,美国下降 15.6%)的年龄调整死亡率均有所下降。然而,在 45 岁至 65 岁的人群中,KPNC 的下降幅度明显大于美国,心脏病(KPNC 下降 48.3%,美国下降 23.6%)、冠心病(KPNC 下降 55.6%,美国下降 35.9%)、中风(KPNC 下降 55.8%,美国下降 26.0%)和全因死亡率(KPNC 下降 31.5%,美国下降 9.1%)均有所下降。性别特异性变化大致相似。
尽管心脏病和中风死亡率显著下降,但与大型综合医疗服务系统相比,全国年龄在 65 岁以下人群的改善仍存在差距。针对脆弱的中年人群开展改善心血管死亡率的干预措施可能对缩小这一差距发挥关键作用。