Faculty of Medicine and Life Sciences, University of Tampere, P.O. Box 100, 33014, Tampere, Finland.
Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, 60220 Seinäjoki, Finland.
Psychiatry Res. 2018 Jun;264:31-38. doi: 10.1016/j.psychres.2018.03.073. Epub 2018 Mar 28.
Patients with depression and alcohol use disorder frequently present with elevated markers of inflammation. Adipose tissue may function as a source for inflammation, yet the interplay between adiposity, alcohol use and depression has remained unknown. We examined 242 patients, referred to treatment for depressive symptoms, and followed for a period of 6 months. The assessments included screening for alcohol use and measurements of body mass index, serum adiponectin, leptin, resistin, progranulin, hs-CRP, IL-6 and MCP-1 at baseline and after 6 months of treatment. During follow-up, mean MADRS and AUDIT scores decreased significantly, whereas BMI increased. The changes in the levels of cytokines and adipokines were influenced by alcohol consumption and adiposity in a gender-dependent manner. The presence of AUD seemed to particularly influence the levels of cytokines. The levels of IL-6, hs-CRP, progranulin, and leptin differed between AUD and non-AUD groups at baseline, but no longer at 6 months. Baseline levels of leptin and resistin were higher in women and changes occurring in leptin, progranulin, and adiponectin were more notable in women. The data indicates significant gender-dependent interactions between depression, alcohol and mediators of inflammation, which should be considered in studies on the pathogenesis of depression and its comorbidities.
患有抑郁症和酒精使用障碍的患者通常会出现炎症标志物升高的情况。脂肪组织可能是炎症的来源，但肥胖、酒精使用和抑郁之间的相互作用仍不清楚。我们检查了 242 名因抑郁症状就诊并接受 6 个月治疗的患者。评估包括酒精使用筛查以及在基线和治疗 6 个月后测量血清脂联素、瘦素、抵抗素、颗粒蛋白前体、hs-CRP、IL-6 和 MCP-1。在随访期间，MADRS 和 AUDIT 评分的平均值显著降低，而 BMI 增加。细胞因子和脂肪因子水平的变化受性别依赖性的酒精消耗和肥胖的影响。AUD 的存在似乎特别影响细胞因子的水平。在基线时，AUD 和非 AUD 组之间的 IL-6、hs-CRP、颗粒蛋白前体和瘦素水平存在差异，但在 6 个月时不再存在差异。基线时女性的瘦素和抵抗素水平较高，而瘦素、颗粒蛋白前体和脂联素的变化在女性中更为明显。这些数据表明，抑郁、酒精和炎症介质之间存在显著的性别依赖性相互作用，在研究抑郁及其合并症的发病机制时应考虑这些相互作用。
