RNA 结合蛋白在肠道上皮生物学和结直肠癌中的作用。
RNA Binding Proteins in Intestinal Epithelial Biology and Colorectal Cancer.
机构信息
Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, 421 Curie Blvd., Philadelphia, PA 19104, USA.
Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, 421 Curie Blvd., Philadelphia, PA 19104, USA.
出版信息
Trends Mol Med. 2018 May;24(5):490-506. doi: 10.1016/j.molmed.2018.03.008. Epub 2018 Apr 5.
Abstract
The intestinal epithelium is highly proliferative and consists of crypt invaginations that house stem cells and villus projections with differentiated cells. There exists a dynamic equilibrium between proliferation, migration, differentiation, and senescence that is regulated by several factors. Among these are RNA binding proteins (RBPs) that bind their targets in a both context dependent and independent manner. RBP-RNA complexes act as rheostats by regulating expression of RNAs both co- and post-transcriptionally. This is important, especially in response to intestinal injury, to fuel regeneration. The manner in which these RBPs function in the intestine and their interactions with other pivotal pathways in colorectal cancer may provide a framework for new insights and potential therapeutic applications.
摘要
肠上皮细胞具有高度的增殖能力，由隐窝内陷形成，其中包含干细胞和绒毛突起上的分化细胞。增殖、迁移、分化和衰老之间存在着动态平衡，这一平衡受到多种因素的调节。其中包括 RNA 结合蛋白 (RBPs)，它们以依赖和不依赖上下文的方式结合其靶标。RBP-RNA 复合物通过在共转录和转录后水平上调节 RNA 的表达来充当变阻器。这一点非常重要，尤其是在应对肠道损伤以促进再生时。这些 RBPs 在肠道中的作用方式及其与结直肠癌中其他关键途径的相互作用，可能为新的见解和潜在的治疗应用提供框架。
相似文献
1
RNA Binding Proteins in Intestinal Epithelial Biology and Colorectal Cancer.RNA 结合蛋白在肠道上皮生物学和结直肠癌中的作用。
Trends Mol Med. 2018 May;24(5):490-506. doi: 10.1016/j.molmed.2018.03.008. Epub 2018 Apr 5.
2
Jnk2 deletion disrupts intestinal mucosal homeostasis and maturation by differentially modulating RNA-binding proteins HuR and CUGBP1.Jnk2 缺失通过差异调节 RNA 结合蛋白 HuR 和 CUGBP1 破坏肠道黏膜稳态和成熟。
Am J Physiol Cell Physiol. 2014 Jun 15;306(12):C1167-75. doi: 10.1152/ajpcell.00093.2014. Epub 2014 Apr 16.
3
RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer.RNA 结合蛋白（RBPs）及其在癌症中 DNA 损伤和辐射反应中的作用。
Adv Drug Deliv Rev. 2022 Dec;191:114569. doi: 10.1016/j.addr.2022.114569. Epub 2022 Oct 14.
4
RNA binding protein RBM3 increases β-catenin signaling to increase stem cell characteristics in colorectal cancer cells.RNA结合蛋白RBM3增强β-连环蛋白信号传导，从而增加结肠癌细胞的干细胞特性。
Mol Carcinog. 2016 Nov;55(11):1503-1516. doi: 10.1002/mc.22404. Epub 2015 Aug 31.
5
Competition between RNA-binding proteins CELF1 and HuR modulates MYC translation and intestinal epithelium renewal.RNA结合蛋白CELF1和HuR之间的竞争调节MYC的翻译及肠上皮更新。
Mol Biol Cell. 2015 May 15;26(10):1797-810. doi: 10.1091/mbc.E14-11-1500. Epub 2015 Mar 25.
6
Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy.Mex-3 RNA 结合家族成员 A（MEX3A）/circMPP6 复合物通过抑制自噬促进结直肠癌的进展。
Signal Transduct Target Ther. 2024 Apr 2;9(1):80. doi: 10.1038/s41392-024-01787-3.
7
CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness.CDX2 的调控作用：RNA 结合蛋白 MEX3A 对肠道分化和干性的影响。
Nucleic Acids Res. 2013 Apr;41(7):3986-99. doi: 10.1093/nar/gkt087. Epub 2013 Feb 13.
8
The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine.LIN28B-IMP1 转录后调控物对肠道中的致癌信号有相反的影响。
Genes Dev. 2018 Aug 1;32(15-16):1020-1034. doi: 10.1101/gad.314369.118.
9
Expression of putative stem cell genes Musashi-1 and beta1-integrin in human colorectal adenomas and adenocarcinomas.Musashi-1 和β1-整合素这两个假定的干细胞基因在人结直肠腺瘤和腺癌中的表达。
Int J Colorectal Dis. 2010 Jan;25(1):17-23. doi: 10.1007/s00384-009-0791-2. Epub 2009 Aug 29.
10
The RNA-binding protein HuR regulates intestinal epithelial restitution by modulating Caveolin-1 gene expression.RNA 结合蛋白 HuR 通过调节 Cav-1 基因表达来调节肠道上皮修复。
Biochem J. 2021 Jan 15;478(1):247-260. doi: 10.1042/BCJ20200372.
引用本文的文献
1
Evaluating the potential of GSPT2 and CIRBP as biomarkers in endometrial cancer: Multicenter RT-PCR and IHC study.评估GSPT2和CIRBP作为子宫内膜癌生物标志物的潜力：多中心逆转录聚合酶链反应和免疫组化研究
Medicine (Baltimore). 2025 Aug 29;104(35):e43627. doi: 10.1097/MD.0000000000043627.
2
RBM47 functions as an anti-oncogene by regulating expression and alternative splicing of cell proliferation and apoptosis associated genes in colorectal cancer cells.RBM47通过调节结肠癌细胞中细胞增殖和凋亡相关基因的表达及可变剪接发挥抑癌基因的作用。
Sci Rep. 2025 Jul 22;15(1):26685. doi: 10.1038/s41598-025-05151-5.
3
p52-ZER6/DAZAP1 axis promotes ferroptosis resistance and colorectal cancer progression regulating mRNA stabilization.p52-ZER6/DAZAP1轴通过调节mRNA稳定性促进铁死亡抗性和结直肠癌进展。
Acta Pharm Sin B. 2025 Apr;15(4):2039-2058. doi: 10.1016/j.apsb.2025.02.013. Epub 2025 Feb 17.
4
The emerging role of intestinal stem cells in ulcerative colitis.肠道干细胞在溃疡性结肠炎中的新作用。
Front Med (Lausanne). 2025 Mar 25;12:1569328. doi: 10.3389/fmed.2025.1569328. eCollection 2025.
5
Construction of a TP53 mutation-associated ceRNA network as prognostic biomarkers in hepatocellular carcinoma.构建作为肝细胞癌预后生物标志物的TP53突变相关ceRNA网络
Heliyon. 2024 Apr 30;10(9):e30066. doi: 10.1016/j.heliyon.2024.e30066. eCollection 2024 May 15.
6
Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review.CUG 结合蛋白 1（CELF1）在生理平衡和疾病中的作用：系统评价。
Cell Mol Biol Lett. 2024 Mar 5;29(1):32. doi: 10.1186/s11658-024-00556-y.
7
Transcriptome signatures of host tissue infected with African swine fever virus reveal differential expression of associated oncogenes.感染非洲猪瘟病毒的宿主组织转录组特征揭示了相关癌基因的差异表达。
Arch Virol. 2024 Feb 21;169(3):54. doi: 10.1007/s00705-023-05959-4.
8
Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells.Staufen1 通过稳定结直肠癌细胞中的 FOXA1 mRNA 来抑制 FOXA1 调节的转录组。
Mol Cell Biol. 2024;44(2):43-56. doi: 10.1080/10985549.2024.2307574. Epub 2024 Feb 12.
9
Development and validation of a prognostic model based on RNA binding proteins in patients with esophageal cancer.基于RNA结合蛋白的食管癌患者预后模型的建立与验证
J Thorac Dis. 2023 Nov 30;15(11):6178-6191. doi: 10.21037/jtd-23-1307. Epub 2023 Nov 27.
10
Core clock gene BMAL1 and RNA-binding protein MEX3A collaboratively regulate Lgr5 expression in intestinal crypt cells.核心时钟基因 BMAL1 和 RNA 结合蛋白 MEX3A 协同调节肠道隐窝细胞中 Lgr5 的表达。
Sci Rep. 2023 Oct 16;13(1):17597. doi: 10.1038/s41598-023-44997-5.
本文引用的文献
1
Complex HuR function in pancreatic cancer cells.胰腺癌细胞中复杂的 HuR 功能。
Wiley Interdiscip Rev RNA. 2018 May;9(3):e1469. doi: 10.1002/wrna.1469. Epub 2018 Feb 16.
2
Silencing Lin28 promotes apoptosis in colorectal cancer cells by upregulating let‑7c targeting of antiapoptotic BCL2L1.沉默 Lin28 通过上调 let-7c 靶向抗凋亡 BCL2L1 促进结直肠癌细胞凋亡。
Mol Med Rep. 2018 Apr;17(4):5143-5149. doi: 10.3892/mmr.2018.8483. Epub 2018 Jan 25.
3
A brave new world of RNA-binding proteins.RNA 结合蛋白的崭新世界。
Nat Rev Mol Cell Biol. 2018 May;19(5):327-341. doi: 10.1038/nrm.2017.130. Epub 2018 Jan 17.
4
Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers.全面解析 RNA 结合蛋白在人类癌症中的特征
Cell Rep. 2018 Jan 2;22(1):286-298. doi: 10.1016/j.celrep.2017.12.035.
5
Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.系统分析确定了由 RNA 结合蛋白 CELF1 控制的富含黑色素瘤的促癌基因网络。
Nat Commun. 2017 Dec 21;8(1):2249. doi: 10.1038/s41467-017-02353-y.
6
High RNA-Binding Motif Protein 3 (RBM3) Expression is Independently Associated with Prolonged Overall Survival in Intestinal-Type Gastric Cancer.高 RNA 结合基序蛋白 3（RBM3）表达与肠型胃癌的总生存时间延长独立相关。
Med Sci Monit. 2017 Dec 21;23:6033-6041. doi: 10.12659/msm.905314.
7
Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer.拓展视野：非典型 RNA 结合蛋白在癌症中的新作用。
Curr Opin Genet Dev. 2018 Feb;48:112-120. doi: 10.1016/j.gde.2017.11.006. Epub 2017 Dec 5.
8
Inhibition of CUG-binding protein 1 and activation of caspases are critically involved in piperazine derivative BK10007S induced apoptosis in hepatocellular carcinoma cells.CUG结合蛋白1的抑制和半胱天冬酶的激活在哌嗪衍生物BK10007S诱导的肝癌细胞凋亡中起关键作用。
PLoS One. 2017 Oct 16;12(10):e0186490. doi: 10.1371/journal.pone.0186490. eCollection 2017.
9
Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution.单核苷酸分辨率下鉴定的 LIN28-RNA 结合位点的比较分析。
RNA Biol. 2017 Dec 2;14(12):1756-1765. doi: 10.1080/15476286.2017.1356566. Epub 2017 Oct 9.
10
Mex3a expression and survival analysis of bladder urothelial carcinoma.膀胱尿路上皮癌的Mex3a表达及生存分析
Oncotarget. 2017 Jun 7;8(33):54764-54774. doi: 10.18632/oncotarget.18399. eCollection 2017 Aug 15.
Zotero 插件