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综合健康生活方式与老年人的发病残疾:大崎 cohort2006 研究。

Combined healthy lifestyle behaviours and incident disability in an elderly population: the Ohsaki Cohort 2006 Study.

机构信息

Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.

Department of Primary Care and Public Health, Imperial College London, London, UK.

出版信息

J Epidemiol Community Health. 2018 Aug;72(8):679-684. doi: 10.1136/jech-2018-210464. Epub 2018 Apr 7.

Abstract

BACKGROUND

The joint impact of healthy lifestyle behaviours (HLBs) on incident disability among elderly populations is still uncertain. This cohort study was conducted to estimate the population-attributable fraction (PAF) of combined HLBs for disability reduction in elderly Japanese.

METHODS

We analysed 10-year follow-up data for 9910 community-dwelling elderly people (≥65 years) in a prospective cohort study. Information on lifestyle behaviours and food consumption was collected via a questionnaire in 2006. The exposure variable was defined as a healthy lifestyle index (HLI), which represented the summed number of HLBs ('never or former smoker', 'time spent walking ≥0.5 hour/day' and 'vegetable and fruit consumption volume ≥median'). Data on incident disability were retrieved from the public Long term Care Insurance database. HRs and 95% CIs were estimated by Cox proportional regression and the PAFs and their 95% CIs were estimated with the multivariate-adjusted model.

RESULTS

The 10-year incidence of disability was 35.7%. An inverse dose-response relationship was observed (HR (95% CI): 0.85(0.81 to 0.90) for each one-point increase of the HLI score, p-trend <0.001). Based on multivariate-adjustment, adherence to each one additional HLB gives PAF of 10.5%(95% CI 9.0% to 12.0%) for disability reduction. The PAF would have been 25.9%(14.2% to 36.0%) if all subjects had adhered to all three HLBs.

CONCLUSION

Combined HLBs may have a substantial impact on reducing the risk of incident disability among elderly people. Even having one more healthy lifestyle habit may bring considerable benefit.

摘要

背景

健康生活方式行为(HLB)对老年人群体发生残疾的综合影响仍不确定。本队列研究旨在估计日本老年人中联合 HLB 对减少残疾的人群归因分数(PAF)。

方法

我们分析了一项前瞻性队列研究中 9910 名居住在社区的老年人(≥65 岁)的 10 年随访数据。2006 年通过问卷收集了生活方式行为和食物消耗信息。暴露变量定义为健康生活方式指数(HLI),代表 HLB 的总和数(从不或曾经吸烟、每天散步时间≥0.5 小时和蔬菜和水果消耗量中位数)。残疾发生的数据从公共长期护理保险数据库中检索。使用 Cox 比例风险回归估计 HR 和 95%CI,使用多变量调整模型估计 PAF 和 95%CI。

结果

10 年残疾发生率为 35.7%。观察到了一个反向剂量反应关系(HR(95%CI):HLI 评分每增加 1 分,为 0.85(0.81 至 0.90),趋势检验 p<0.001)。基于多变量调整,每增加一个 HLB,残疾风险的 PAF 为 10.5%(95%CI 9.0%至 12.0%)。如果所有受试者都坚持所有三种 HLB,PAF 将为 25.9%(14.2%至 36.0%)。

结论

联合 HLB 可能对降低老年人发生残疾的风险产生重大影响。即使只有一种更健康的生活方式习惯,也可能带来相当大的益处。

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