Santa Monica Orthopaedic and Sports Medicine Group, Santa Monica, California, U.S.A..
Santa Monica Orthopaedic and Sports Medicine Group, Santa Monica, California, U.S.A.
Arthroscopy. 2018 May;34(5):1719-1729. doi: 10.1016/j.arthro.2018.01.048. Epub 2018 Apr 5.
Biological-based therapies for cartilage pathology have gained considerable recognition in the last few decades due to their potential benefits including their minimal invasiveness, capacity for unprecedented healing, and potential for rapid recovery. Consequently, these therapies are likely to have the most noteworthy impact on patients with degenerative joint changes who want to remain active. Currently, the most researched treatments include platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and cell-based therapies. Although further basic science research and well-designed randomized clinical trials are needed to elucidate the long-term role of these therapies in the treatment of osteoarthritis, there is compelling evidence for their use for certain indications. This article aims to review the existing literature for biological-based treatment options for osteoarthritis, critically assessing the current evidence-based recommendations and identify potential avenues for development.
由于其潜在的益处，包括微创性、前所未有的愈合能力和快速恢复的潜力，基于生物学的软骨病理学治疗方法在过去几十年中得到了广泛的认可。因此，这些治疗方法可能对希望保持活跃的退行性关节变化患者产生最显著的影响。目前，研究最多的治疗方法包括富含血小板的血浆（PRP）、骨髓抽吸浓缩物（BMAC）和基于细胞的治疗方法。尽管需要进一步的基础科学研究和精心设计的随机临床试验来阐明这些治疗方法在治疗骨关节炎中的长期作用，但有确凿的证据表明它们在某些适应症中的应用。本文旨在回顾骨关节炎的基于生物学的治疗选择的现有文献，批判性评估当前的循证建议，并确定潜在的发展途径。
