Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Korea.
Exp Mol Med. 2018 Apr 9;50(4):1-7. doi: 10.1038/s12276-018-0025-1.
Classical studies have shown that neuronal immediate-early genes (IEGs) play important roles in synaptic processes critical for key brain functions. IEGs are transiently activated and rapidly upregulated in discrete neurons in response to a wide variety of cellular stimuli, and they are uniquely involved in various aspects of synapse development. In this review, we summarize recent studies of a subset of neuronal IEGs in regulating synapse formation, transmission, and plasticity. We also discuss how the dysregulation of neuronal IEGs is associated with the onset of various brain disorders and pinpoint key outstanding questions that should be addressed in this field.
经典研究表明，神经元即刻早期基因（IEGs）在突触过程中发挥重要作用，这些突触过程对大脑的关键功能至关重要。IEGs 会被各种细胞刺激物短暂激活并迅速上调，它们专门参与突触发育的各个方面。在这篇综述中，我们总结了最近关于调节突触形成、传递和可塑性的神经元 IEG 的一部分研究。我们还讨论了神经元 IEG 的失调如何与各种脑部疾病的发生有关，并指出了该领域应解决的关键问题。
