卵巢癌肿瘤干细胞样细胞的表面标志物及其临床相关性
Surface markers of cancer stem-like cells of ovarian cancer and their clinical relevance.
作者信息
Klemba Aleksandra, Purzycka-Olewiecka J Karolina, Wcisło Gabriel, Czarnecka Anna M, Lewicki Sławomir, Lesyng Bogdan, Szczylik Cezary, Kieda Claudine
机构信息
Department of Oncology, Military Institute of Medicine, Warsaw, Poland.
College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Poland.
出版信息
Contemp Oncol (Pozn). 2018 Mar;22(1A):48-55. doi: 10.5114/wo.2018.73885. Epub 2018 Mar 5.
Cancer stem-like cells (CSLCs) are defined as cancer cells with stem cell characteristics. Although CSLCs constitute no more than a few percent of the tumor mass, they play important roles in cancer chemo-resistance, metastasis and disease recurrence. Ovarian cancer (OC) is considered the most aggressive gynecological malignancy in which the role of CSLCs is of major significance, although it remains to be specified. The studies describing ovarian CSLC phenotype vary in the definition of the molecular pattern of expression of the main markers such as CD133, CD44, CD117, and CD24. Stem-like features of OC have been shown to correlate with the clinical course of the disease and permit diagnosis, prognosis and treatment outcome to be improved. Identification of CSLC markers could provide hallmarks which, related to the chemo-resistance of the disease, will facilitate treatment selection. This review describes recent advances in research on stem-like cell status in OC, mainly focusing on surface markers of CSLCs and their clinical relevance.
癌症干细胞样细胞（CSLCs）被定义为具有干细胞特征的癌细胞。尽管CSLCs在肿瘤组织中所占比例不超过百分之几，但它们在癌症化疗耐药、转移和疾病复发中发挥着重要作用。卵巢癌（OC）被认为是最具侵袭性的妇科恶性肿瘤，其中CSLCs的作用至关重要，尽管仍有待明确。描述卵巢CSLC表型的研究在主要标志物如CD133、CD44、CD117和CD24的分子表达模式定义上存在差异。OC的干细胞样特征已被证明与疾病的临床进程相关，并有助于改善诊断、预后和治疗结果。CSLC标志物的鉴定可以提供与疾病化疗耐药相关的特征，从而有助于治疗选择。本综述描述了OC中干细胞样细胞状态的研究进展，主要关注CSLCs的表面标志物及其临床相关性。
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