Jeon So Hyeon, Kim Yong Pyo, Kho Younglim, Shin Jeoung Hwa, Ji Won Hyun, Ahn Yun Gyong
Western Seoul Center, Korea Basic Science Institute, Seoul 03759, Republic of Korea.
Department of Environmental Science and Engineering, Ewha Womans University, Seoul 03759, Republic of Korea.
J Anal Methods Chem. 2018 Feb 5;2018:9470254. doi: 10.1155/2018/9470254. eCollection 2018.
A method for the quantitative determination of dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylhexyl) adipate (DEHA), bis(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), dioctyl terephthalate (DOTP), diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP) in medical infusion sets was developed and validated using gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) in the multiple reaction monitoring (MRM) mode. Solvent extraction with polymer dissolution for sample preparation was employed prior to GC-MS/MS analysis. Average recoveries of the eight target analytes are typically in the range of 91.8-122% with the relative standard deviations of 1.8-17.8%. The limits of quantification (LOQs) of the analytical method were in the ranges of 54.1 to 76.3 ng/g. Analysis using GC-MS/MS provided reliable performance, as well as higher sensitivity and selectivity than GC-MS analysis, especially for the presence of minority plasticizers at different concentrations.
建立了一种使用气相色谱-三重四极杆质谱联用仪（GC-MS/MS）在多反应监测（MRM）模式下定量测定医用输液器中邻苯二甲酸二丁酯（DBP）、邻苯二甲酸丁苄酯（BBP）、己二酸二（2-乙基己基）酯（DEHA）、邻苯二甲酸二（2-乙基己基）酯（DEHP）、邻苯二甲酸二正辛酯（DNOP）、对苯二甲酸二辛酯（DOTP）、邻苯二甲酸二异壬酯（DINP）和邻苯二甲酸二异癸酯（DIDP）的方法，并进行了验证。在GC-MS/MS分析之前，采用聚合物溶解溶剂萃取法进行样品制备。8种目标分析物的平均回收率通常在91.8%至122%之间，相对标准偏差为1.8%至17.8%。该分析方法的定量限（LOQ）在54.1至76.3 ng/g范围内。使用GC-MS/MS进行分析具有可靠的性能，并且比GC-MS分析具有更高的灵敏度和选择性，特别是对于不同浓度下微量增塑剂的存在。
