State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Xue Yuan Road 38 , Beijing 100191 , China.
State Key Laboratory of Organometallic Chemistry , Chinese Academy of Sciences , Shanghai 200032 , China.
Chem Rev. 2018 May 23;118(10):4912-4945. doi: 10.1021/acs.chemrev.7b00193. Epub 2018 Apr 9.
Oxygenases-catalyzed reductive activation of molecular oxygen and incorporation of O atoms into an organic molecule is undoubtedly one of the most attractive research areas. Typically, these oxygenation reactions proceed with high selectivity and reactivity, which is seldom found in its "biomimetic" chemocatalytic counterparts. Furthermore, enzymatic oxygenation can avoid undesired overoxidation, which is frequently observed in (industrial) chemical transformation. Therefore, it is not surprising that tremendous attention has been paid to enzymatic oxygenation. Their application in organic synthesis has been steadily growing over the years. The goal of the present Review is to provide a handy reference for chemists interested in using homogeneous oxygenase catalysis and those interested in discovering new types of biomimetic oxidations and oxygenations with dioxygen. In this Review, we will review the recent advances in in homogeneous oxygenase catalysis to reveal the great achievements and potentials in this field.
加氧酶催化的分子氧还原活化以及氧原子掺入有机分子中无疑是最具吸引力的研究领域之一。通常情况下，这些氧合反应具有很高的选择性和反应活性，这在其“模拟生物”的均相催化对应物中很少见。此外，酶促氧合可以避免在（工业）化学转化中经常观察到的不必要的过度氧化。因此，人们对酶促氧合给予了极大的关注。它们在有机合成中的应用多年来一直在稳步增长。本综述的目的是为有兴趣使用均相加氧酶催化以及有兴趣发现新型模拟生物氧化和用氧气进行氧合的化学家提供一个方便的参考。在本综述中，我们将回顾均相加氧酶催化的最新进展，揭示该领域的巨大成就和潜力。
