Gramatté Johannes, Pietzsch Jens, Bergmann Ralf, Richter Torsten
Department of Anesthesia and Intensive Care, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
Department of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
Clin Hemorheol Microcirc. 2018;69(1-2):187-195. doi: 10.3233/CH-189113.
Aspiration of low-pH gastric fluid leads to an initial pneumonitis, which may become complicated by subsequent pneumonia or acute respiratory distress syndrome. Current treatment is at best supportive, but there is growing experimental evidence on the significant contribution of both neutrophils and platelets in the development of this inflammatory pulmonary reaction, a condition that can be attenuated by several medicinal products. This review aims to summarize novel findings in experimental models on pathomechanisms after an acid-aspiration event. Given the clinical relevance, specific emphasis is put on deduced potential experimental therapeutic approaches, which make use of the characteristic alteration of microcirculation in the injured lung.
吸入低pH值胃液会引发初始的肺炎，随后可能并发肺炎或急性呼吸窘迫综合征。目前的治疗充其量只是支持性的，但越来越多的实验证据表明，中性粒细胞和血小板在这种炎症性肺部反应的发展中起着重要作用，而几种药物产品可以减轻这种情况。这篇综述旨在总结酸吸入事件后病理机制的实验模型中的新发现。鉴于其临床相关性，特别强调了推导得出的潜在实验性治疗方法，这些方法利用了受损肺脏微循环的特征性改变。
