威氏马兜铃芽中二萜类化合物抗乙型肝炎病毒活性研究。
Diterpenes from buds of Wikstroemia chamaedaphne showing anti-hepatitis B virus activities.
机构信息
Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, PR China.
Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, PR China; College of Chemistry & Chemical Engineering, Shanxi University, Taiyuan, 030006, PR China.
出版信息
Phytochemistry. 2018 Jul;151:17-25. doi: 10.1016/j.phytochem.2018.01.021. Epub 2018 Apr 6.
Phytochemical study of the buds of Wikstroemia chamaedaphne Meisn. led to the isolation of seven previously undescribed diterpenes, including one tigliane diterpene (wikstchalide A), two daphnane diterpenes (wikstroelides W-X), and four lathyrane diterpenes (laurifoliosides A-B and 2-epi-laurifoliosides A-B), along with four known diterpenes. The structures of these compounds were established by extensive spectroscopic evidence and electronic circular dichroism (ECD) calculations. Wikstchalide A possesses a 5,6-epoxy ring in the tigliane skeleton. Two compounds exhibited potential anti-hepatitis B virus activities, with IC values of 46.5 and 88.3 μg/mL against hepatitis B virus (HBV) surface antigen (HBsAg), and six compounds showed certain inhibitory effects on HBV-DNA replication with the inhibition ratios ranging from 2.0% to 33.0% at the concentrations ranging from 0.39 to 6.25 μg/mL.
对密花树 Wikstroemia chamaedaphne Meisn. 的花蕾进行的植物化学研究导致分离出了七种以前未描述的二萜，包括一种丁香烷二萜（wikstchalide A）、两种瑞香烷二萜（wikstroelides W-X）和四种拉蒂烷二萜（laurifoliosides A-B 和 2-epi-laurifoliosides A-B），以及四种已知的二萜。这些化合物的结构通过广泛的光谱证据和电子圆二色性（ECD）计算确定。Wikstchalide A 在丁香烷骨架中具有 5,6-环氧环。两种化合物表现出潜在的抗乙型肝炎病毒（HBV）活性，对乙型肝炎病毒表面抗原（HBsAg）的 IC 值分别为 46.5 和 88.3 μg/mL，六种化合物对 HBV-DNA 复制具有一定的抑制作用，在 0.39 至 6.25 μg/mL 的浓度范围内，抑制率范围为 2.0%至 33.0%。
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