从. 中分离得到的抗 HIV 雷公藤二萜。
Anti-HIV Tigliane Diterpenoids from .
机构信息
Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
出版信息
J Nat Prod. 2020 Dec 24;83(12):3584-3590. doi: 10.1021/acs.jnatprod.0c00700. Epub 2020 Nov 10.
Abstract
During a chemical investigation of , three new [wikstrocins A-C (-)] and three known tigliane diterpenoids (-) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds ( and ) showed potent anti-HIV activity with IC values of 3.8 and 12.8 nM, respectively.
摘要
在对 的化学成分研究中，分离得到了三个新的[wikstrocins A-C (-)]和三个已知的丁香烷二萜类化合物(-)。通过广泛的物理化学和光谱分析阐明了新化合物的结构。还评估了丁香烷的ECD 手性效应与 B 环结构之间的相关性。对分离得到的化合物进行了抗 HIV 活性测试，评估它们对 MT4 细胞中 HIV-1 感染的抑制作用，其中两个化合物（和）表现出较强的抗 HIV 活性，IC 值分别为 3.8 和 12.8 nM。
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