Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Molecules. 2012 May 29;17(6):6424-33. doi: 10.3390/molecules17066424.
Two new diterpenoids, wikstroelide Q (1) and prostratin Q (5), together with three known diterpenoids, pimelea factors P₂ (2), P₃ (3), and prostratin (4), and five known lignans, (+)-epipioresinol (6), (+)-isolariciresinol (7), (−)-lariciresinol (8), (+)-epi-sesaminone (9), and prestegane B (10), were isolated from the buds of Wikstroemia chamaedaphne Meissn. Their structures were elucidated by a combination of spectroscopic analyses. Compounds 1–10 were evaluated for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines in vitro.
从密花树 Wikstroemia chamaedaphne Meissn 的芽中分离得到了两个新的二萜类化合物 wikstroelide Q（1）和 prostratin Q（5），以及三个已知的二萜类化合物 pimelea factors P₂（2）、P₃（3）和 prostratin（4），以及五个已知的木脂素类化合物 (+)-epipioresinol（6）、(+)-isolariciresinol（7）、(-)-lariciresinol（8）、(+)-epi-sesaminone（9）和 prestegane B（10）。通过光谱分析的组合，确定了它们的结构。对化合物 1-10 进行了体外细胞毒性测试，评估了它们对 HL-60、SMMC-7721、A549、MCF-7、SW480 和 BEAS-2B 细胞系的抑制作用。
