Wikstroemia chamaedaphne 芽中二新二萜

Two new diterpenoids from the buds of Wikstroemia chamaedaphne.

机构信息

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

出版信息

Molecules. 2012 May 29;17(6):6424-33. doi: 10.3390/molecules17066424.

DOI:10.3390/molecules17066424

PMID:22643353

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6268896/

Abstract

Two new diterpenoids, wikstroelide Q (1) and prostratin Q (5), together with three known diterpenoids, pimelea factors P₂ (2), P₃ (3), and prostratin (4), and five known lignans, (+)-epipioresinol (6), (+)-isolariciresinol (7), (−)-lariciresinol (8), (+)-epi-sesaminone (9), and prestegane B (10), were isolated from the buds of Wikstroemia chamaedaphne Meissn. Their structures were elucidated by a combination of spectroscopic analyses. Compounds 1–10 were evaluated for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines in vitro.

摘要

从密花树 Wikstroemia chamaedaphne Meissn 的芽中分离得到了两个新的二萜类化合物 wikstroelide Q（1）和 prostratin Q（5），以及三个已知的二萜类化合物 pimelea factors P₂（2）、P₃（3）和 prostratin（4），以及五个已知的木脂素类化合物 (+)-epipioresinol（6）、(+)-isolariciresinol（7）、(-)-lariciresinol（8）、(+)-epi-sesaminone（9）和 prestegane B（10）。通过光谱分析的组合，确定了它们的结构。对化合物 1-10 进行了体外细胞毒性测试，评估了它们对 HL-60、SMMC-7721、A549、MCF-7、SW480 和 BEAS-2B 细胞系的抑制作用。