超声分子成像剂。
Molecular imaging agents for ultrasound.
机构信息
Department of Radiology, Molecular Imaging Program at Stanford, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA, United States.
Department of Radiology, Molecular Imaging Program at Stanford, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA, United States; Department of Bioengineering, Department of Materials Science and Engineering, Stanford University, Stanford, CA, United States.
出版信息
Curr Opin Chem Biol. 2018 Aug;45:113-120. doi: 10.1016/j.cbpa.2018.03.017. Epub 2018 Apr 7.
Abstract
Ultrasound (US) imaging is a safe, sensitive and affordable imaging modality with a wide usage in the clinic. US signal can be further enhanced by using echogenic contrast agents (UCAs) which amplify the US signal. Developments in UCAs which are targeted to sites of disease allow the use of US imaging to provide molecular information. Unfortunately, traditional UCAs are too large to leave the vascular space limiting the application of molecular US to intravascular markers. In this mini review, we highlight the most recent reports on the application of molecular US imaging in the clinic and summarize the latest nanoparticle platforms used to develop nUCAs. We believe that the highlighted technologies will have a great impact on the evolution of the US imaging field.
摘要
超声（US）成像是一种安全、敏感且经济实惠的成像方式，在临床中有广泛的应用。使用超声造影剂（UCAs）可以进一步增强 US 信号，这些造影剂可以放大 US 信号。针对疾病部位的靶向 UCAs 的发展允许使用 US 成像来提供分子信息。不幸的是，传统的 UCAs 太大，无法离开血管空间，从而限制了分子 US 在血管内标志物中的应用。在这篇迷你综述中，我们重点介绍了分子 US 成像在临床中的最新应用报告，并总结了最新的用于开发 nUCA 的纳米颗粒平台。我们相信，所强调的技术将对 US 成像领域的发展产生重大影响。
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