一种新型碳糊电极，修饰有 MWCNTs 和纳米结构分子印迹聚合物，用于痕量三丙咪嗪的测定：电极组件混合对其性能的关键影响。
A new carbon paste electrode modified with MWCNTs and nano-structured molecularly imprinted polymer for ultratrace determination of trimipramine: The crucial effect of electrode components mixing on its performance.
机构信息
Department of Analytical Chemistry, Faculty of Chemistry, University College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.
Department of Analytical Chemistry, Faculty of Chemistry, University College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.
出版信息
Biosens Bioelectron. 2018 Jul 15;111:27-33. doi: 10.1016/j.bios.2018.03.061. Epub 2018 Mar 28.
A novel carbon nanocomposite paste electrode was prepared and used as a voltammetric sensor for ultratrace determination of trimipramine (TRI) which currently used for the treatment of psychiatric disorders. For this aim, nanoparticles of molecularly imprinted polymer (MIP), synthesized by precipitation polymerization method, and multi-walled carbon nanotubes (MWCNTs) were embedded in a nanocomposite paste electrode. The nanocomposite mixing style demonstrated a significant influence on the final electrode performance. The sensor exhibited linear response range of 1.0 × 10-2.5 × 10 mol L and very high sensitivity of 2131 μA μ mol L. The lower detection limit of the sensor was calculated to be 4.5 × 10 mol L (S/N = 3). This sensor was applied successfully for highly selective determination of TRI in pharmaceutical formulations, urine and serum samples without applying any sample pretreatment.
一种新型的碳纳米复合糊电极被制备出来，并被用作伏安传感器，用于痕量测定曲米帕明（TRI）。目前 TRI 被用于治疗精神疾病。为此，通过沉淀聚合方法合成的分子印迹聚合物（MIP）纳米粒子和多壁碳纳米管（MWCNTs）被嵌入在纳米复合糊电极中。纳米复合材料的混合方式对最终电极性能有显著影响。该传感器具有 1.0×10-2.5×10 mol L 的线性响应范围和非常高的灵敏度 2131 μA μmol L。传感器的检测下限计算为 4.5×10 mol L（S/N=3）。该传感器无需进行任何样品预处理，成功地应用于药物制剂、尿液和血清样品中 TRI 的高选择性测定。
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