Department of Ophthalmology, Weill Cornell Medicine, New York, NY.
Department of Ophthalmology, Queen's University, Hotel Dieu Hospital, Kingston, Ont.
Can J Ophthalmol. 2018 Apr;53(2):168-172. doi: 10.1016/j.jcjo.2017.08.006. Epub 2017 Oct 25.
To assess subjective and quantified metamorphopsia, as well as vision-related quality of life (QOL), in patients with age-related macular degeneration (AMD) to determine whether there is a correlation between quantified metamorphopsia and vision-related QOL in patients with AMD.
A cross-sectional study of patients with AMD. Patients who had a best-corrected visual acuity less than 20/200, vitreomacular adhesion, vitreomacular traction, epiretinal membrane, macular hole, macular edema by causes other than AMD, diabetic retinopathy, retinal detachment, previous retinal surgery, glaucoma, amblyopia, or strabismus were excluded. Subjective perceptions of metamorphopsia were captured by a validated 10-item questionnaire. M-CHARTS (Inami, Japan) was used to detect quantified metamorphopsia. Quantified metamorphopsia was scored horizontally and vertically. The mean values of 3 repeated examinations were used for data analysis. The 25-item National Eye Institute Visual Functioning Questionnaire (VFQ-25) was used to assess vision-related QOL.
Among 102 eyes with AMD, the most commonly reported subjective perception of metamorphopsia included lines of words on books, newspapers, or computer displays (45.1%), followed by frames of windows or bookshelves (22.6%), lines of tiles on bathroom wall (21.6%), and people's faces (18.6%). Eyes with wet AMD had significantly higher horizontal and vertical metamorphopsia scores compared with eyes with dry AMD (p < 0.0001). The higher horizontal metamorphopsia score and the higher vertical metamorphopsia score between the 2 eyes were both negatively correlated with the NEI VFQ-25 composite score (Spearman rank correlation r = -0.3207, p = 0.0010; Spearman rank correlation r = -0.3190, p = 0.0011).
In our study, the most common subjective metamorphopsia was distortion of lines of words on books, newspapers, or computer displays. Compared to eyes with dry AMD, those with wet AMD had higher quantified horizontal and vertical metamorphopsia. Between the 2 eyes, both the higher horizontal and vertical metamorphopsia scores were correlated with the NEI VFQ-25 composite score.
评估与年龄相关的黄斑变性（AMD）患者的主观和量化的视物变形，以及与视觉相关的生活质量（QOL），以确定 AMD 患者的量化视物变形与与视觉相关的 QOL 是否存在相关性。
这是一项 AMD 患者的横断面研究。排除最佳矫正视力低于 20/200、玻璃体黄斑粘连、玻璃体黄斑牵引、视网膜内膜、黄斑裂孔、由 AMD 以外的原因引起的黄斑水肿、糖尿病性视网膜病变、视网膜脱离、先前的视网膜手术、青光眼、弱视或斜视的患者。通过验证的 10 项问卷来捕捉主观的视物变形感知。使用 M-CHARTS（日本 Inami）来检测量化的视物变形。量化的视物变形进行水平和垂直评分。分析数据时使用 3 次重复检查的平均值。使用 25 项国家眼科研究所视觉功能问卷（VFQ-25）来评估与视觉相关的 QOL。
在 102 只 AMD 眼中，最常报告的主观视物变形感知包括书本、报纸或计算机显示器上的文字线（45.1%），其次是窗户或书架的边框（22.6%）、浴室墙上的瓷砖线（21.6%）和人的脸（18.6%）。湿性 AMD 眼的水平和垂直视物变形评分明显高于干性 AMD 眼（p<0.0001）。两眼之间较高的水平和垂直视物变形评分均与 NEI VFQ-25 综合评分呈负相关（Spearman 等级相关 r=-0.3207，p=0.0010；Spearman 等级相关 r=-0.3190，p=0.0011）。
在我们的研究中，最常见的主观视物变形是书本、报纸或计算机显示器上的文字线扭曲。与干性 AMD 眼相比，湿性 AMD 眼的量化水平和垂直视物变形更高。两眼之间，较高的水平和垂直视物变形评分均与 NEI VFQ-25 综合评分相关。
