Impact of genetic variants on uterine cervical cancer clinicopathologic characteristics.

To date, no study delineates the relationships among the genetic variants of () and uterine cervical carcinogenesis as well as clinicopathological parameters and 5 years survival of cervical cancer patients in Taiwan. Therefore, the involvement of polymorphisms in cervical cancer was investigated. Genotypic frequencies of three polymorphisms rs6501551, rs9914618 and rs11655237 were determined in 199 patients including 115 patients with invasive cancer, 84 with precancerous lesions, and 274 control females using real-time polymerase chain reaction. It revealed that polymorphisms were not found significantly related to development of cervical cancer. Cervical cancer patients with genotypes AG/GG in rs6501551 had more risk to have tumor diameter larger than 4 cm as compared to those with genotype AA (=0.043). Cervical cancer patients with genotype GG in rs6501551 had worse 5 years survival as compared to those with genotypes AA/AG in multivariate analysis (hazard ratio: 4.70; =0.097). However, only two patients exhibiting GG were noted, and one had mortality, another had no mortality. In conclusion, larger sample size needs to verify the associations of genetic variants with clinicopathological parameters and patient survival of cervical cancer for Taiwanese females.