Dahllöf G, Barr M, Bolme P, Modéer T, Lönnqvist B, Ringdén O, Heimdahl A
Department of Pedodontics, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden.
Oral Surg Oral Med Oral Pathol. 1988 Jan;65(1):41-4. doi: 10.1016/0030-4220(88)90189-2.
The dental status of 16 children who had been treated with bone marrow transplantation (BMT) for serious bone marrow diseases was followed for up to 6 years. Several types of disturbances in dental development were observed in children who had been conditioned with total body irradiation (TBI) at 10 Gy before BMT. Thus, impaired root development that caused short V-shaped roots was found in all patients, a complete failure of root development and premature apical closure were found in five patients, enamel hypoplasia was observed in four patients, and microdontia was observed in three patients conditioned with TBI. Patients younger than 6 years of age at BMT exhibited the most severe and extensive dental aberrations. The TBI at 10 Gy appeared to be the major cause of the disturbances found.
对16名因严重骨髓疾病接受骨髓移植（BMT）治疗的儿童的牙齿状况进行了长达6年的跟踪。在BMT前接受10 Gy全身照射（TBI）预处理的儿童中观察到几种牙齿发育障碍类型。因此，在所有患者中均发现导致短V形根的牙根发育受损，5名患者出现牙根发育完全失败和根尖过早闭合，4名患者观察到釉质发育不全，3名接受TBI预处理的患者观察到过小牙。BMT时年龄小于6岁的患者表现出最严重和广泛的牙齿畸形。10 Gy的TBI似乎是所发现障碍的主要原因。
