Veronese Nicola, Ragusa Francesco Saverio, Dominguez Ligia J, Cusumano Claudia, Barbagallo Mario
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Department of Medicine and Surgery, Kore University of Enna, Piazza dell'Università, Enna, 94100, Italy.
Aging Clin Exp Res. 2024 Dec 3;36(1):231. doi: 10.1007/s40520-024-02883-8.
The Mediterranean diet has gained significant attention for its potential health benefits on diverse pathological conditions including osteoarthritis (OA), a prevalent degenerative joint disease characterized by cartilage breakdown and inflammation. Numerous observational studies have suggested that adherence to the Mediterranean diet, may have protective effects against OA. The abundance of antioxidants and anti-inflammatory compounds and omega-3 fatty acids, among the Mediterranean diet components is believed to contribute to its beneficial effects on OA. Research investigating the association between the Mediterranean diet and OA has shown promising results. Several observational studies have reported that adherence to the Mediterranean diet is associated with a reduced risk of developing OA and with lower severity of OA symptoms. Additionally, intervention studies have demonstrated improvements in pain, function, and quality of life among OA patients following a Mediterranean diet intervention. Furthermore, emerging evidence suggests potential mechanisms underlying the protective effects of the Mediterranean diet against OA, including its ability to reduce inflammation, oxidative stress, and cartilage degradation. However, further well-designed randomized controlled trials and mechanistic studies are needed to elucidate the precise mechanisms and establish causality. In conclusion, the Mediterranean diet appears to be a promising dietary approach for the prevention and management of OA. Its rich array of nutrients and bioactive compounds may exert protective effects against OA development and progression, although more research is warranted to confirm these findings and elucidate underlying mechanisms.
地中海饮食因其对包括骨关节炎（OA）在内的多种病理状况可能具有的健康益处而受到广泛关注。骨关节炎是一种常见的退行性关节疾病，其特征是软骨破坏和炎症。众多观察性研究表明，坚持地中海饮食可能对骨关节炎具有保护作用。地中海饮食中的抗氧化剂、抗炎化合物和omega-3脂肪酸含量丰富，据信这有助于其对骨关节炎产生有益影响。关于地中海饮食与骨关节炎之间关联的研究已显示出有前景的结果。多项观察性研究报告称，坚持地中海饮食与患骨关节炎风险降低以及骨关节炎症状严重程度较低有关。此外，干预性研究表明，骨关节炎患者在地中海饮食干预后，疼痛、功能和生活质量都有所改善。此外，新出现的证据表明了地中海饮食对骨关节炎保护作用的潜在机制，包括其减轻炎症、氧化应激和软骨降解的能力。然而，需要进一步设计完善的随机对照试验和机制研究来阐明确切机制并确定因果关系。总之，地中海饮食似乎是预防和管理骨关节炎的一种有前景的饮食方法。其丰富的营养成分和生物活性化合物可能对骨关节炎的发展和进展发挥保护作用，尽管需要更多研究来证实这些发现并阐明潜在机制。
