Lee Sol Moe, Lee Wonseok, Lee Yeong Seon, Yoo Jin-Soo, Park Soo-Jung, Kim Heebal, Kim Su Yeon
a Division of Bacterial Disease Research, Center for Infectious Diseases Research , Korea National Institute of Health, Centers for Disease Control & Prevention , Cheongju-si , Chungcheongbuk-do , South Korea.
b Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences , Seoul National University , Seoul , South Korea.
Prion. 2018 Mar 4;12(2):138-142. doi: 10.1080/19336896.2018.1461519. Epub 2018 May 4.
Prion diseases are fatal neurodegenerative disorders that affect humans and animals. Although various small molecules have been evaluated for application in the treatment of prion diseases, none have been shown to be efficacious. Expanding our knowledge of these molecules is important for understanding of the complex mechanisms of prion diseases. To improve access to the scattered information on small molecules related to prion diseases, we built a database of therapeutic molecules associated with prion diseases (THERPA, therpa.pythonanywhere.com). THERPA includes 119 small molecules and their 283 relationships with prion diseases. THERPA is an interactive visual database and useful for improving search efficiency which can help researchers identify intrinsic small molecules that can be used for developing therapeutics for prion diseases.
朊病毒疾病是影响人类和动物的致命性神经退行性疾病。尽管已经评估了各种小分子用于治疗朊病毒疾病，但尚无一种被证明是有效的。扩展我们对这些分子的了解对于理解朊病毒疾病的复杂机制很重要。为了更方便地获取与朊病毒疾病相关的小分子的分散信息，我们建立了一个与朊病毒疾病相关的治疗性分子数据库（THERPA，therpa.pythonanywhere.com）。THERPA包含119种小分子及其与朊病毒疾病的283种关系。THERPA是一个交互式可视化数据库，有助于提高搜索效率，可帮助研究人员识别可用于开发朊病毒疾病治疗药物的内在小分子。
