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THERPA v2: an update of a small molecule database related to prion protein regulation and prion disease progression.

作者信息

Lee Sol Moe, Kim Sung Soon, Kim Heebal, Kim Su Yeon

机构信息

Division of Bacterial Disease Research, Center for Infectious Diseases Research, Korea National Institute of Health, Centers for Disease Control & Prevention, Cheongju-si, South Korea.

Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, South Korea.

出版信息

Prion. 2019 Jan;13(1):197-198. doi: 10.1080/19336896.2019.1689789.

DOI:10.1080/19336896.2019.1689789
PMID:31752585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8647720/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/309d/8647720/76ede02fe608/KPRN_A_1689789_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/309d/8647720/76ede02fe608/KPRN_A_1689789_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/309d/8647720/76ede02fe608/KPRN_A_1689789_F0001_OC.jpg

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THERPA v2: an update of a small molecule database related to prion protein regulation and prion disease progression.THERPA v2:与朊病毒蛋白调控及朊病毒疾病进展相关的小分子数据库的更新
Prion. 2019 Jan;13(1):197-198. doi: 10.1080/19336896.2019.1689789.
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THERPA: A small molecule database related to prion protein regulation and prion diseases progression.THERPA:一个与朊病毒蛋白调控和朊病毒疾病进展相关的小分子数据库。
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Abnormal Expression of Proteolytic Stress-Related Proteins and Protective Effect of Fibrinolytic Enzymes in Prion Diseases.朊病毒疾病中蛋白水解应激相关蛋白的异常表达及纤溶酶的保护作用
Transbound Emerg Dis. 2025 Feb 26;2025:9527934. doi: 10.1155/tbed/9527934. eCollection 2025.
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Transcriptomic analysis identifies novel potential biomarkers and highlights cilium-related biological processes in the early stages of prion disease in mice.转录组分析鉴定了新型潜在生物标志物,并强调了在小鼠朊病毒病早期阶段与纤毛相关的生物学过程。
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本文引用的文献

1
Poly-L-histidine inhibits prion propagation in a prion-infected cell line.聚-L-组氨酸抑制朊病毒在朊病毒感染的细胞系中的传播。
Prion. 2018;12(3-4):226-233. doi: 10.1080/19336896.2018.1505395. Epub 2018 Aug 17.
2
Identification of Alprenolol Hydrochloride as an Anti-prion Compound Using Surface Plasmon Resonance Imaging.利用表面等离子体共振成像技术鉴定盐酸阿普洛尔为抗朊病毒化合物。
Mol Neurobiol. 2019 Jan;56(1):367-377. doi: 10.1007/s12035-018-1088-7. Epub 2018 Apr 27.
3
THERPA: A small molecule database related to prion protein regulation and prion diseases progression.
THERPA:一个与朊病毒蛋白调控和朊病毒疾病进展相关的小分子数据库。
Prion. 2018 Mar 4;12(2):138-142. doi: 10.1080/19336896.2018.1461519. Epub 2018 May 4.
4
Prion diseases and the BSE crisis.朊病毒疾病与疯牛病危机。
Science. 1997 Oct 10;278(5336):245-51. doi: 10.1126/science.278.5336.245.
5
Novel proteinaceous infectious particles cause scrapie.新型蛋白质感染性颗粒可引发羊瘙痒病。
Science. 1982 Apr 9;216(4542):136-44. doi: 10.1126/science.6801762.