3rd Department of Internal Medicine, Hypertension-24 h ABPM ESH Center of Excellence, Papageorgiou Hospital, Aristotle University of Thessaloniki, Greece.
Institute for Clinical Pharmacology, Medical School Hannover, Hannover, Germany.
J Hypertens. 2018 Jul;36(7):1427-1440. doi: 10.1097/HJH.0000000000001730.
: Obesity is a key factor for cardiovascular diseases and complications. Obesity is associated with hypertension, dyslipidemia and type II diabetes, which are the major predictors of cardiovascular disease in the future. It predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke that are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key roles in the prevention are strategies to increase physical exercise, reduce body weight and to prevent or treat hypertension, lipids disorders and diabetes earlier and efficiently to prevent cardiovascular complications.Epidemiology and mechanisms of obesity-induced hypertension, diabetes and dyslipidemia will be reviewed and the role of lifestyle modification and treatment strategies in obesity will be updated and analyzed. The best treatment options for people with obesity, hypertension, diabetes and dyslipidemia will discussed.
肥胖是心血管疾病和并发症的一个关键因素。肥胖与高血压、血脂异常和 2 型糖尿病有关，这些都是未来心血管疾病的主要预测因素。它易患心房颤动、心力衰竭、心源性猝死、肾脏疾病和缺血性中风，这些都是心血管住院和死亡的主要原因。由于肥胖以及对血管和心脏的心血管影响早在生命早期就开始了，甚至从儿童期就开始了，因此，在疾病表现出现之前，通过健康政策非常早地预防肥胖非常重要。预防的关键作用是增加体育锻炼、减轻体重的策略，以及更早、更有效地预防和治疗高血压、血脂异常和糖尿病，以预防心血管并发症。将对肥胖引起的高血压、糖尿病和血脂异常的流行病学和机制进行综述，并更新和分析生活方式改变和治疗策略在肥胖中的作用。将讨论肥胖、高血压、糖尿病和血脂异常患者的最佳治疗选择。
