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Folic acid throughout pregnancy: too much?孕期全程补充叶酸：过量了吗？
Am J Clin Nutr. 2018 Apr 1;107(4):497-498. doi: 10.1093/ajcn/nqy055.
2
Maternal folic acid supplementation modulates DNA methylation and gene expression in the rat offspring in a gestation period-dependent and organ-specific manner.孕期补充母体叶酸以孕期依赖和器官特异性方式调节大鼠后代的DNA甲基化和基因表达。
J Nutr Biochem. 2016 Jul;33:103-10. doi: 10.1016/j.jnutbio.2016.03.018. Epub 2016 Apr 7.
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Folic acid supplementation in pregnancy and prevention of fetal neural tube defects.妊娠补充叶酸与预防胎儿神经管缺陷。
Przegl Epidemiol. 2020;74(2):362-369. doi: 10.32394/pe.74.29.
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Maternal use of folic acid supplements and infant risk of neural tube defects in Norway 1999-2013.1999 - 2013年挪威孕妇叶酸补充剂的使用情况与婴儿神经管缺陷风险
Scand J Public Health. 2016 Aug;44(6):619-26. doi: 10.1177/1403494816649494. Epub 2016 May 19.
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Effect of periconceptional folic acid supplementation on the risk of neural tube defects associated with a previous spontaneous abortion or maternal first-trimester fever.补充围孕期叶酸对既往自发性流产或孕妇孕早期发热相关神经管缺陷风险的影响。
Hum Reprod. 2019 Aug 1;34(8):1587-1594. doi: 10.1093/humrep/dez112.
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Folate deficiency disturbs hsa-let-7 g level through methylation regulation in neural tube defects.叶酸缺乏通过甲基化调控影响 hsa-let-7g 在神经管缺陷中的水平。
J Cell Mol Med. 2017 Dec;21(12):3244-3253. doi: 10.1111/jcmm.13228. Epub 2017 Jun 19.
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[Neural tube defects and folic acid].
Duodecim. 1996;112(11):975-82.
8
Periconceptional folic acid-containing multivitamin supplementation for the prevention of neural tube defects and cardiovascular malformations.围孕期含叶酸的多种维生素补充剂用于预防神经管缺陷和心血管畸形。
Ann Nutr Metab. 2011;59(1):38-40. doi: 10.1159/000332125. Epub 2011 Nov 25.
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Acid folic and pregnancy: A mandatory supplementation.叶酸酸与妊娠：强制性补充。
Ann Endocrinol (Paris). 2018 Apr;79(2):91-94. doi: 10.1016/j.ando.2017.10.001. Epub 2018 Feb 9.
10
Folic acid in pregnancy and fetal outcomes.孕期叶酸与胎儿结局
J Obstet Gynaecol. 2008 Jan;28(1):3-13. doi: 10.1080/01443610701814195.

引用本文的文献

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Maternal folic acid and multivitamin supplementation: International clinical evidence with considerations for the prevention of folate-sensitive birth defects.孕期补充叶酸和多种维生素：预防叶酸敏感型出生缺陷的国际临床证据及考量
Prev Med Rep. 2021 Oct 25;24:101617. doi: 10.1016/j.pmedr.2021.101617. eCollection 2021 Dec.
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Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study.天然（6S）-5-甲基四氢叶酸在增加妊娠期间血清和红细胞叶酸浓度方面是否与合成叶酸同样有效？一项概念验证性 pilot 研究。
Trials. 2020 May 5;21(1):380. doi: 10.1186/s13063-020-04320-3.
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A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57.一项关于妊娠叶酸干预的随机对照试验凸显了 ZFP57 上一个假定的甲基化调控控制元件。
Clin Epigenetics. 2019 Feb 18;11(1):31. doi: 10.1186/s13148-019-0618-0.

本文引用的文献

1
Gene-specific DNA methylation in newborns in response to folic acid supplementation during the second and third trimesters of pregnancy: epigenetic analysis from a randomized controlled trial.孕期第二和第三 trimester 补充叶酸对新生儿基因特异性 DNA 甲基化的影响：一项随机对照试验的表观遗传学分析。
Am J Clin Nutr. 2018 Apr 1;107(4):566-575. doi: 10.1093/ajcn/nqx069.
2
Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation.睾丸 MTHFR 缺乏可能解释了与高剂量叶酸补充相关的精子 DNA 低甲基化。
Hum Mol Genet. 2018 Apr 1;27(7):1123-1135. doi: 10.1093/hmg/ddy021.
3
Impact of folic acid intake during pregnancy on genomic imprinting of and 1-carbon metabolism.孕期叶酸摄入对[具体基因]及一碳代谢基因组印记的影响。 （注：原文中“of and”部分缺失具体基因信息）
FASEB J. 2017 Dec;31(12):5149-5158. doi: 10.1096/fj.201601214RR. Epub 2017 Aug 4.
4
The interplay between DNA methylation, folate and neurocognitive development.DNA甲基化、叶酸与神经认知发育之间的相互作用。
Epigenomics. 2016 Jun;8(6):863-79. doi: 10.2217/epi-2016-0003. Epub 2016 Jun 20.
5
The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects.长期每日补充叶酸和维生素B12对老年受试者全基因组DNA甲基化的影响。
Clin Epigenetics. 2015 Nov 14;7:121. doi: 10.1186/s13148-015-0154-5. eCollection 2015.
6
Cesarean delivery and hematopoietic stem cell epigenetics in the newborn infant: implications for future health?剖宫产术与新生儿造血干细胞表观遗传学：对未来健康的影响？
Am J Obstet Gynecol. 2014 Nov;211(5):502.e1-8. doi: 10.1016/j.ajog.2014.05.014. Epub 2014 Jul 1.
7
Neural tube defects, folic acid and methylation.神经管缺陷、叶酸和甲基化。
Int J Environ Res Public Health. 2013 Sep 17;10(9):4352-89. doi: 10.3390/ijerph10094352.
8
Folic acid food fortification-its history, effect, concerns, and future directions.叶酸食物强化——历史、效果、关注问题和未来方向。
Nutrients. 2011 Mar;3(3):370-84. doi: 10.3390/nu3030370. Epub 2011 Mar 15.
9
Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy.IGF2 差异甲基化区域的甲基化变异与母亲在怀孕前后叶酸的使用。
Epigenetics. 2011 Jul;6(7):928-36. doi: 10.4161/epi.6.7.16263. Epub 2011 Jul 1.
10
Epigenetic modulation at birth - altered DNA-methylation in white blood cells after Caesarean section.出生时的表观遗传调控——剖宫产术后白细胞中DNA甲基化的改变
Acta Paediatr. 2009 Jul;98(7):1096-9. doi: 10.1111/j.1651-2227.2009.01371.x.

Folic acid throughout pregnancy: too much?

作者信息

Schrott Rose, Murphy Susan K

机构信息

University Program in Environmental Health, Duke Nicholas School of the Environment, and Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC.

出版信息

Am J Clin Nutr. 2018 Apr 1;107(4):497-498. doi: 10.1093/ajcn/nqy055.

DOI:10.1093/ajcn/nqy055
PMID:29635510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6693531/
Abstract
摘要