Haque Mohammad Rafiul, Ansari H Shahid
Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
HIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India.
Drug Res (Stuttg). 2018 Nov;68(11):637-647. doi: 10.1055/a-0590-1956. Epub 2018 Apr 10.
Arq zeera is a distillate product that prepared from four different herbs namely Trachyspermum ammi L., apiaceae, Zingiber officinale Roxb., zingiberaceae, Carum carvi L.,apiaceae and Cuminum cyminum L., apiaceae. The present study aims to determine the antiobesity effect of arq zeera and its main components thymol and cuminaldehyde in high fat diet induced obese rats and to explore its mechanism of action. In current study, orlistat was used as positive controls. Male Wistar rats were fed with HFD for 42 days to induce obesity. HFD-fed rats were administered with arq zeera, thymol, cumic aldehyde, thymol + cuminaldehyde and orlistat for 28 days. During the course of treatment, body weight and food intake frequently observed and after end of treatments, liver weight, visceral fat pad weight, plasma lipid proflie, alanine aminotransferase, aspartate aminotransferase, glucose, insulin, leptin levels and pancreatic lipase activity were studied on all treated obese rats. The histopathology of liver was also studied. After the treatments of arq zeera and its main components, body weight, food intake, liver weight, visceral fat pad weight and the level of lipid profile, alanine aminotransferase, aspartate aminotranferase, glucose, insulin, and leptin were found to be decreased and pancreatic lipase inhibition were increased. Arq zeera showed more potential antiobesity effect than orlistat. According to our present findings, arq zeera and its main components possessed potent antiobesity effect on high fat diet -induced obese rats and excreted anti-obesity effect partly via hypolipidemic, hypoglycemic, hypoinsulinemic, hypoleptinemic and pancreatic lipase inhibition action.
阿尔克孜然是一种馏出物产品，由四种不同的草药制备而成，即伞形科的孜然芹、姜科的姜、伞形科的葛缕子和伞形科的孜然。本研究旨在确定阿尔克孜然及其主要成分百里香酚和枯茗醛对高脂饮食诱导的肥胖大鼠的抗肥胖作用，并探讨其作用机制。在当前研究中，奥利司他用作阳性对照。雄性Wistar大鼠喂食高脂饮食42天以诱导肥胖。给喂食高脂饮食的大鼠施用阿尔克孜然、百里香酚、枯茗醛、百里香酚+枯茗醛和奥利司他28天。在治疗过程中，频繁观察体重和食物摄入量，治疗结束后，对所有接受治疗的肥胖大鼠研究肝脏重量、内脏脂肪垫重量、血浆脂质谱、丙氨酸转氨酶、天冬氨酸转氨酶、葡萄糖、胰岛素、瘦素水平和胰脂肪酶活性。还研究了肝脏的组织病理学。用阿尔克孜然及其主要成分治疗后，发现体重、食物摄入量、肝脏重量、内脏脂肪垫重量以及脂质谱、丙氨酸转氨酶、天冬氨酸转氨酶、葡萄糖、胰岛素和瘦素水平降低，胰脂肪酶抑制作用增强。阿尔克孜然显示出比奥利司他更强的抗肥胖作用。根据我们目前的研究结果，阿尔克孜然及其主要成分对高脂饮食诱导的肥胖大鼠具有强大的抗肥胖作用，并且部分通过降血脂、降血糖、降胰岛素、降瘦素和抑制胰脂肪酶的作用发挥抗肥胖作用。
