Aruna V, Amruthavalli G V, Gayathri R
Dr. JRK's Research and Pharmaceuticals Pvt. Ltd., Chennai, India.
J Cosmet Dermatol. 2019 Feb;18(1):221-225. doi: 10.1111/jocd.12544. Epub 2018 Apr 10.
Psoriasis being an incurable disease, the drug dependency of the patient in most occasions causes greater health problem than psoriasis. Wherever there is flare-up, immunosuppressive drugs and other antimitotic medicaments are necessary. Therefore, a safe cosmetic preparation with drug-like effect on certain triggering factors of psoriasis may revolutionize the treatment.
Objectives of this study were to determine the effect of the developed formulation on several key enzymes such as lipoxygenase, collagenase, elastase, and nullifying the free radicals and glycation. All these enzymes have cascading effect in triggering the problem to inflammatory level.
Biochemical and enzymatic assay was performed to determine the effect of the cosmetic formulation and its effective dosage.
The findings clearly show that the formulation is effective against all the key triggering factors of psoriasis.
Findings undoubtedly establish the drug-like effect of nondrug formulation (cosmetic formulation). The use of this formulation may minimize the relative dependency of many steroids and other medicament. As the formulation contains only proven cosmetic ingredients and herbs, long-term use is unlikely to produce any side effects.
银屑病是一种无法治愈的疾病，在大多数情况下，患者对药物的依赖所导致的健康问题比银屑病本身更为严重。每当病情发作时，免疫抑制药物和其他抗有丝分裂药物都是必需的。因此，一种对银屑病某些触发因素具有类似药物作用的安全化妆品制剂可能会彻底改变治疗方法。
本研究的目的是确定所开发制剂对几种关键酶（如脂氧合酶、胶原酶、弹性蛋白酶）的作用，并消除自由基和糖化反应。所有这些酶在将问题引发到炎症水平方面具有级联效应。
进行生化和酶学分析以确定化妆品制剂的效果及其有效剂量。
研究结果清楚地表明，该制剂对银屑病的所有关键触发因素均有效。
研究结果无疑证实了非药物制剂（化妆品制剂）具有类似药物的作用。使用该制剂可能会最大限度地减少对许多类固醇和其他药物的相对依赖。由于该制剂仅含有经证实的化妆品成分和草药，长期使用不太可能产生任何副作用。
