Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, United States.
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, United States.
Mol Immunol. 2019 Sep;113:67-74. doi: 10.1016/j.molimm.2018.03.027. Epub 2018 Apr 7.
The presentation of virus-derived peptides by MHC molecules constitutes the earliest signals for immune recognition by T cells. In HIV infection, immune responses elicited during infection do not enable to clear infection and correlates of immune protection are not well defined. Here we review features of antigen processing and presentation specific to HIV, analyze how HIV has adapted to the antigen processing machinery and discuss how advances in biochemical and computational protein degradation analyses and in immunopeptidome definition may help identify targets for efficient immune clearance and vaccine immunogen design.
病毒衍生肽由 MHC 分子呈递构成了 T 细胞免疫识别的最早信号。在 HIV 感染中，感染期间引发的免疫应答并不能清除感染，且免疫保护的相关因素也尚未明确。在此，我们回顾了 HIV 特有的抗原加工和呈递特征，分析了 HIV 如何适应抗原加工机制，并讨论了生化和计算蛋白降解分析以及免疫肽组定义方面的进展如何有助于确定有效免疫清除和疫苗免疫原设计的靶标。
