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提取物可减轻四氧嘧啶诱导的实验性糖尿病大鼠的高血糖症，并预防各种器官毒性。

Extracts Attenuate Hyperglycemia and Protect against Various Organ Toxicities in Alloxan-Induced Experimental Diabetic Rats.

作者信息

Tiss Mohamed, Hamden Khaled

机构信息

Laboratory of Bioresources Integrative Biology and Exploiting, Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir, Tunisia.

出版信息

Evid Based Complement Alternat Med. 2022 Aug 30;2022:6816942. doi: 10.1155/2022/6816942. eCollection 2022.

DOI:10.1155/2022/6816942
PMID:36082185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9448544/
Abstract

In this study, we attempted for the first time to determine the phytochemical compositions and biopharmaceutical properties of methanol extract (GAME) and water extract (GAWE). High-performance liquid chromatography with diode array detection (HPLC-DAD) analysis was performed to establish the chemical profile of the investigated extracts. Chemical composition analysis was taken in the presence of various bioactive compounds such as quercetin 7-O-glucoside and apigenin 7-O-glucoside in GAME. In GAWE, various abundant compounds were found in the extract such as quercetin 7-O-glucoside, apigenin, quercetin, apigenin 7-O-glucoside, and cinnamic acid. This study showed that the administration of GAWE and GAME to type 1 diabetic rats decreased fasting blood glucose, protected pancreas -cells from death and injury, increased liver glycogen rate, and ameliorated oral glucose tolerance test. Moreover, GA reduced weight loss, and diabetes decreased basic physical activity. In addition, the administration of GA extracts in diabetic rats protected from diabetes-induced liver, kidney, testes, heart, and bone toxicities. GAWE has possible value for antidiabetic oral medication.

摘要

在本研究中，我们首次尝试确定甲醇提取物（GAME）和水提取物（GAWE）的植物化学成分及生物药学特性。采用带二极管阵列检测的高效液相色谱法（HPLC-DAD）分析来确定所研究提取物的化学特征。对GAME中存在的各种生物活性化合物（如槲皮素7-O-葡萄糖苷和芹菜素7-O-葡萄糖苷）进行了化学成分分析。在GAWE中，提取物中发现了各种丰富的化合物，如槲皮素7-O-葡萄糖苷、芹菜素、槲皮素、芹菜素7-O-葡萄糖苷和肉桂酸。本研究表明，给1型糖尿病大鼠施用GAWE和GAME可降低空腹血糖，保护胰腺β细胞免于死亡和损伤，提高肝糖原率，并改善口服葡萄糖耐量试验。此外，GA减轻体重减轻，糖尿病降低基础身体活动。此外，给糖尿病大鼠施用GA提取物可预防糖尿病引起的肝脏、肾脏、睾丸、心脏和骨骼毒性。GAWE在抗糖尿病口服药物方面具有潜在价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/0187a9552c37/ECAM2022-6816942.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/d288bc4275a9/ECAM2022-6816942.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/d242294bb915/ECAM2022-6816942.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/d98b860aa120/ECAM2022-6816942.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/11e2a2d20229/ECAM2022-6816942.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/3a765562bfe4/ECAM2022-6816942.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/326ced16c9b4/ECAM2022-6816942.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/86300357f56c/ECAM2022-6816942.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/0187a9552c37/ECAM2022-6816942.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/d288bc4275a9/ECAM2022-6816942.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/d242294bb915/ECAM2022-6816942.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/d98b860aa120/ECAM2022-6816942.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/11e2a2d20229/ECAM2022-6816942.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/3a765562bfe4/ECAM2022-6816942.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/326ced16c9b4/ECAM2022-6816942.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/86300357f56c/ECAM2022-6816942.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d35/9448544/0187a9552c37/ECAM2022-6816942.008.jpg

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本文引用的文献

[1]
Protective effect of vanillic acid against diabetes and diabetic nephropathy by attenuating oxidative stress and upregulation of NF-κB, TNF-α and COX-2 proteins in rats.

Phytother Res. 2022-3

[2]
Molecular mechanisms and applications of tea polyphenols: A narrative review.

J Food Biochem. 2021-10

[3]
The anti-obesity and gut microbiota modulating effects of taxifolin in C57BL/6J mice fed with a high-fat diet.

J Sci Food Agric. 2022-3-15

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Nephroprotective effect of Vanillic acid in STZ-induced diabetic rats.

J Diabetes Metab Disord. 2021-4-3

[5]
improves reproductive parameters in alloxan-induced male diabetic rats.

3 Biotech. 2021-2

[6]
Cardioprotective Activities of Ethanolic Extract Root of on Alloxan-Induced Cardiotoxicity in Diabetic Rats.

Biomed Res Int. 2020

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Water Extract of Bunge Improves Hepatic Glucose Homeostasis by Regulating Gluconeogenesis and Glycogen Synthesis in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Mice.

Front Nutr. 2020-9-15

[8]
Erica multiflora extract rich in quercetin-3-O-glucoside and kaempferol-3-O-glucoside alleviates high fat and fructose diet-induced fatty liver disease by modulating metabolic and inflammatory pathways in Wistar rats.

J Nutr Biochem. 2020-12

[9]
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Diabetes Res Clin Pract. 2019-11-14

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Diabetes Res Clin Pract. 2019-9-10

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