Rodrigues Charlene M C, Maiden Martin C J
Department of Zoology, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford, UK.
F1000Res. 2018 Mar 27;7:401. doi: 10.12688/f1000research.13793.1. eCollection 2018.
Bacterial meningitis remains an important cause of global morbidity and mortality. Although effective vaccinations exist and are being increasingly used worldwide, bacterial diversity threatens their impact and the ultimate goal of eliminating the disease. Through genomic epidemiology, we can appreciate bacterial population structure and its consequences for transmission dynamics, virulence, antimicrobial resistance, and development of new vaccines. Here, we review what we have learned through genomic epidemiological studies, following the rapid implementation of whole genome sequencing that can help to optimise preventative strategies for bacterial meningitis.
细菌性脑膜炎仍然是全球发病和死亡的一个重要原因。尽管有有效的疫苗且在全球范围内的使用越来越广泛，但细菌的多样性威胁着它们的效果以及消除该疾病的最终目标。通过基因组流行病学，我们能够了解细菌种群结构及其对传播动态、毒力、抗菌药物耐药性和新型疫苗研发的影响。在此，我们回顾通过基因组流行病学研究所学到的知识，这些研究是在全基因组测序迅速实施之后开展的，全基因组测序有助于优化细菌性脑膜炎的预防策略。
