Gardy Jennifer L, Loman Nicholas J
British Columbia Centre for Disease Control, Vancouver, British Columbia V5Z 4R4, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Nat Rev Genet. 2018 Jan;19(1):9-20. doi: 10.1038/nrg.2017.88. Epub 2017 Nov 13.
The recent Ebola and Zika epidemics demonstrate the need for the continuous surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast, affordable sequencing of pathogen genomes - now a staple of the public health microbiology laboratory in well-resourced settings - can affect each of these areas. Coupling genomic diagnostics and epidemiology to innovative digital disease detection platforms raises the possibility of an open, global, digital pathogen surveillance system. When informed by a One Health approach, in which human, animal and environmental health are considered together, such a genomics-based system has profound potential to improve public health in settings lacking robust laboratory capacity.
近期的埃博拉和寨卡疫情表明，对新发传染病进行持续监测、快速诊断和实时追踪很有必要。对病原体基因组进行快速且经济高效的测序——如今在资源充足地区已成为公共卫生微生物实验室的一项常规工作——能够在上述各个方面发挥作用。将基因组诊断和流行病学与创新型数字疾病检测平台相结合，有望建立一个开放、全球通用的数字病原体监测系统。当采用“同一健康”方法（即综合考虑人类、动物和环境卫生）时，这样一个基于基因组学的系统在提升实验室能力薄弱地区的公共卫生水平方面具有巨大潜力。
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