Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany ; European Association for Predictive, Preventive & Personalised Medicine, www.epmanet.eu.
EPMA J. 2010 Jun;1(2):237-44. doi: 10.1007/s13167-010-0031-4. Epub 2010 Jun 29.
Prediction and prevention of glaucoma. Neurodegenerative eye disease glaucoma is the second leading cause of blindness with estimated 67 million patients worldwide. Molecular pathomechanisms of glaucoma demonstrate both a considerable overlap with and remarkable particularities compared to other neurodegenerative disorders e.g. Alzheimer's disease. Identification of pathology-specific biomarker-sets is essential to develop advanced diagnostic approaches and personalised patients' treatment. Subcellular imaging and expression patterns in blood as the reliable platform for early/predictive glaucoma diagnosis. Following key pathways are affected in glaucoma pathology: stress response, apoptosis and DNA-repair, adhesion, blood-brain-barrier-breakdown, tissue remodelling, transcription regulation, multidrug resistance and energy metabolism.
青光眼的预测和预防。神经退行性眼病青光眼是全球第二大致盲原因,估计有 6700 万患者。与其他神经退行性疾病(如阿尔茨海默病)相比,青光眼的分子病理机制既有相当大的重叠,也有显著的特殊性。鉴定具有特定病理学的生物标志物集对于开发先进的诊断方法和个性化的患者治疗至关重要。亚细胞成像和血液中的表达模式是早期/预测性青光眼诊断的可靠平台。以下关键途径在青光眼病理中受到影响:应激反应、细胞凋亡和 DNA 修复、黏附、血脑屏障破坏、组织重塑、转录调控、多药耐药和能量代谢。