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硬膜外类固醇注射疗效的回顾性分析

A retrospective analysis of the efficacy of epidural steroid injections.

作者信息

Rosen C D, Kahanovitz N, Bernstein R, Viola K

机构信息

Hospital for Joint Diseases Orthopaedic Institute, New York, New York 10003.

出版信息

Clin Orthop Relat Res. 1988 Mar(228):270-2.

PMID:2963720
Abstract

Forty patients were studied retrospectively to evaluate the effect of epidural steroid injections on low back pain and sciatica characteristic of spinal stenosis or a herniated lumbar disc. All but one of these patients had radicular symptoms. The average age was 55 years, and the average follow-up time was eight months. All patients were injected by the same anesthesiologist with 2 cc of Depomedrol-40. Thirty-six patients received either one, two, or three injections. Four patients received either four or five injections. The overall results were poor, with about 60% of patients reporting varying degrees of relief from leg and back pain immediately after injection. However, at follow-up examination, only 24% were asymptomatic; 40% reported no change in preinjection numbness, weakness, or pain; and approximately 35% had varying degrees of relief with no consistent pattern. Of those who had complete relief, there was no correlation between relief of pain, age, or number of injections. From this study, it appears that approximately 50% of patients with radicular symptoms may receive temporary relief with steroid injection. However, long-term relief occurs in less than 25% of patients.

摘要

对40例患者进行了回顾性研究,以评估硬膜外注射类固醇对腰椎管狭窄症或腰椎间盘突出症所致下腰痛和坐骨神经痛的影响。这些患者中除1例之外均有神经根症状。平均年龄为55岁,平均随访时间为8个月。所有患者均由同一位麻醉医生注射2毫升德宝松-40。36例患者接受了1次、2次或3次注射。4例患者接受了4次或5次注射。总体结果不佳,约60%的患者在注射后立即报告腿部和背部疼痛有不同程度的缓解。然而,在随访检查时,只有24%的患者无症状;40%的患者报告注射前的麻木、无力或疼痛无变化;约35%的患者有不同程度的缓解,但无一致规律。在那些疼痛完全缓解的患者中,疼痛缓解与年龄或注射次数之间无相关性。从这项研究来看,似乎约50%有神经根症状的患者可能通过类固醇注射获得暂时缓解。然而,不到25%的患者能获得长期缓解。

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