Perna G P, Villella A, Stanislao M, Fanelli R, Ficola U, Varraso A, Loperfido F
Servizio di Cardiologia e UTIC, Ospedale Regionale Generale Casa Sollievo della Sofferenza, S. Giovanni Rotondo, FG.
G Ital Cardiol. 1987 Oct;17(10):841-5.
Some recent studies suggest that changes in the endogenous opioid peptides (POE) secretion during stress may be involved in various hemodynamic, respiratory and hormonal responses to exercise. To evaluate the relationship between fitness and POE release, 10 mixed-type exercise trained athletes (A) and 10 sedentary normal controls (C) were examined by bicycle stress testing; maximum oxygen uptake (VO2max) and peak work load (PWL) were greater in A than C (VO2max = 61.8 +/- 5.2 vs 40.2 +/- 6.1 ml/kg; PWL = 1525 +/- 229 vs 915 +/- 305 kgm.both p less than 0.01). After 24 hours A and C underwent rectangular bicycle stress testing (two 20' steps at 60% and 80% VO2max). Total plasmatic beta-endorphin (BEP) and its precursor beta-lipotropin (BLPH) were dosed by radioimmunoassay at rest, at 60% VO2max, at 80% VO2max and after complete recovery. Physical exercise caused a transient rise of BEP + BLPH plasma levels in both A and C. In A the increase was greater and occurred earlier than in C. The POE release under submaximal exercise showed a close correlation with oxygen uptake and therefore with fitness. This relation appeared in A at both low and high effort levels, whereas in C it was more strict at higher effort level. There results suggest that POE system play an important role in the adaptive mechanisms in sport practice.
一些近期研究表明，应激期间内源性阿片肽（POE）分泌的变化可能参与了运动时的各种血液动力学、呼吸及激素反应。为评估健康状况与POE释放之间的关系，对10名混合型运动训练运动员（A组）和10名久坐不动的正常对照者（C组）进行了自行车应激测试；A组的最大摄氧量（VO2max）和峰值工作负荷（PWL）均高于C组（VO2max = 61.8±5.2对40.2±6.1 ml/kg；PWL = 1525±229对915±305 kgm，两者p均小于0.01）。24小时后，A组和C组进行了矩形自行车应激测试（在60%和80%VO2max下分两个20分钟阶段）。通过放射免疫分析法在静息状态、60%VO2max、80%VO2max及完全恢复后测定血浆总β-内啡肽（BEP）及其前体β-促脂素（BLPH）。体育锻炼使A组和C组的BEP + BLPH血浆水平出现短暂升高。A组的升高幅度更大且发生时间更早。次最大运动下的POE释放与摄氧量密切相关，因此也与健康状况相关。这种关系在A组的低强度和高强度运动水平下均有体现，而在C组中，在较高运动强度水平下更为严格。这些结果表明，POE系统在运动实践的适应机制中发挥着重要作用。
