Hao Jing, Yu Jennifer S
Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.
Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH 44195, USA.
Biomedicines. 2018 Apr 8;6(2):42. doi: 10.3390/biomedicines6020042.
Neurodevelopmental programs are frequently dysregulated in cancer. Semaphorins are a large family of guidance cues that direct neuronal network formation and are also implicated in cancer. Semaphorins have two kinds of receptors, neuropilins and plexins. Besides their role in development, semaphorin signaling may promote or suppress tumors depending on their context. Sema3C is a secreted semaphorin that plays an important role in the maintenance of cancer stem-like cells, promotes migration and invasion, and may facilitate angiogenesis. Therapeutic strategies that inhibit Sema3C signaling may improve cancer control. This review will summarize the current research on the Sema3C pathway and its potential as a therapeutic target.
神经发育程序在癌症中常常失调。信号素是一大类引导信号，可指导神经网络的形成，也与癌症有关。信号素有两种受体，即神经纤毛蛋白和丛状蛋白。除了在发育中的作用外，信号素信号传导根据其所处环境可能促进或抑制肿瘤。Sema3C是一种分泌型信号素，在维持癌症干细胞样细胞、促进迁移和侵袭以及可能促进血管生成方面发挥重要作用。抑制Sema3C信号传导的治疗策略可能会改善癌症控制。本综述将总结目前关于Sema3C通路及其作为治疗靶点潜力的研究。
