Gooptu C, Higgins C R, James M P
Department of Dermatology, Royal Berkshire Hospital, Reading, UK.
Clin Exp Dermatol. 2000 May;25(3):183-5. doi: 10.1046/j.1365-2230.2000.00608.x.
The immunomodulatory actions of cimetidine, an H2-receptor antagonist, and its use in the treatment of viral warts has been described previously but its effectiveness is still debated. We report the results in 47 patients with multiple, nongenital viral warts who were treated with oral cimetidine in a 3-month open-label study. The drug was generally well tolerated and 87% of children and 68% of adults improved with treatment. Follow-up data in 65% of the patients showed that there had been no recurrence in the majority of those whose warts had cleared completely during treatment, whereas warts tended to persist or recur in those who had stopped treatment before all the warts had resolved. Our data suggests that cimetidine may be helpful in the treatment of viral warts in both adults and children and supports the need for a randomized controlled trial.
H2受体拮抗剂西咪替丁的免疫调节作用及其在治疗病毒性疣中的应用此前已有描述，但其有效性仍存在争议。我们报告了在一项为期3个月的开放标签研究中，对47例多发性、非生殖器病毒性疣患者口服西咪替丁的治疗结果。该药物总体耐受性良好，87%的儿童和68%的成人经治疗后病情有所改善。65%的患者的随访数据显示，在治疗期间疣体完全清除的大多数患者中未出现复发，而在所有疣体尚未消退之前就停止治疗的患者中，疣体往往持续存在或复发。我们的数据表明，西咪替丁可能有助于治疗成人和儿童的病毒性疣，并支持进行随机对照试验的必要性。
